50 (i 14) Society for Experimental Biology and Medicine. 



to fade. An uneventful recovery followed without any complica- 

 tions whatsoever, the desquamation being branny. There was 

 during the entire illness freedom from respiratory symptoms of all 

 kinds. Even during the preemptive period there were no special 

 local symptoms (morbilli sine catarrho). The patient's subjective 

 condition was not much changed, if at all, at any time during his 

 illness. The appetite continued unimpaired. 



2. In this case the blood was furnished by a well-developed 

 Irish servant girl, 21 years old, who passed through an uncompli- 

 cated attack of typical measles. About 30 hours after the earliest 

 appearance of the rash, which still was coming out upon the ex- 

 tremities, 10 c.c. of blood were withdrawn from a vein at the elbow 

 and distributed equally among 4 flasks each containing 50 c.c. of 

 broth and 25 c.c. of ascites fluid. These flasks all remained per- 

 fectly sterile so far as bacteria demonstrable by the usual methods 

 were concerned. 



After 24 hours at 37 0 C, 5 c.c. of the mixture of blood in 

 ascites broth were injected subcutaneously in the back of M., aged 

 28, who had not had measles so far as he knew and who gave his 

 consent to the experiment. This patient was also recovering from 

 a mild attack of scarlet fever, and had been at the time of inocula- 

 tion for twenty -four days the sole occupant of the isolation room 

 of a general hospital in which at that time there were no other 

 cases of measles. There were no local changes at the site of the 

 injection. The temperature and general condition remained normal 

 until the evening of the eleventh day, when the temperature rose 

 to 99. 8° F., and the next day a mild conjunctivitis already sus- 

 pected a day or so previously became definitely apparent. On the 

 thirteenth day there was some cough, the tonsils were bright red, 

 and there was an increased amount of mucous in the throat. In 

 the afternoon the temperature, which was rising, reached 103 0 F. 

 During the next night a typical rubeolous eruption came out, the 

 first spots being noticed on the nose, and then on the forehead, 

 face, scalp, chest, back and abdomen. The rash consisted of pink 

 macules and papules, which disappeared readily on pressure, being 

 largest and brightest red over the face. The forehead was quite 

 uniformly red. The patient was not seriously ill ; there was some 

 loss of appetite, but he slept well during the night, having been 

 somewhat restless the preceding night. Recovery was prompt. 



