72 (136) Society for Experimental Biology and Medicine. 



tration of the halogen derivatives of the hydrocarbons, and found 

 that one of the results in the disturbance which followed was 

 the elimination of halogen aromatic mercapturic acids, which were 

 regarded as derivatives of cystin. Later, Friedmann investigated 

 these compounds and was able to confirm Baumann's view. The 

 mercapturic acids are derivatives of cystein, the reduction product 

 of cystin. 



This study is a part of an investigation of cystinuria, the view, 

 which has been advanced by previous observers, being taken that 

 the process in brombenzol poisoning is an experimental cystinuria. 

 Dogs were used in these experiments, and were fed on a uniform 

 diet. The animals were catheterized once a day. Analyses of the 

 urine, as complete as possible, were made. The feces were ex- 

 amined for nitrogen and fats. 



During the period of administration of the brombenzol the 

 nitrogen and urea were somewhat increased. The urea followed 

 the total nitrogen closely. The preformed ammonia remained at a 

 level below that of the fore period. The kreatinin estimations did 

 not give results of any distinctness. 



The investigation of the partition of sulfur led to the result that, 

 while the total sulfur excretion was not increased during the ex- 

 periment, there was almost complete suppression of the alkaline 

 sulfates. The excretion of neutral sulfur, represented for the most 

 part in this case by parabromphenyl-mercapturic acid, was increased 

 400%. The curves representing the alkaline and neutral sulfur 

 were antipodes. The ethereal sulfates rose markedly during the 

 feeding period. In one experiment it was shown that during the 

 first two days of the administration the total sulfur excretion re- 

 mained constant, while the total sulfate-sulfur fell rapidly. This 

 period is being made the subject of closer study. 



The chlorin and phosphorous excretion remained practically 

 constant during the experiment. There was increased nitrogen and 

 fat elimination in the feces. 



On section, the animals showed ulceration of stomach and in- 

 testines. Microscopically, the liver and kidneys were markedly 

 degenerated. The investigation is being continued. 



