Scientific Proceedings. 



(HO 77 



new bile ducts is readily demonstated. Multinucleated liver cells 

 containing four, to twelve nuclei are very abundant in the late 

 stages. An interesting pheomenon is the englobing and removal of 

 the hyaline remains of necrotic liver cells by large multinucleated 

 masses of protoplasm. These giant cells, essentially foreign body 

 giant cells, are derived in part from endothelial cells, but many 

 have all the characteristics of true hepatic cells and are, undoubt- 

 edly, multinucleated liver cells with phagocytic properties. 



The oldest lesion obtained (thirty-sixth day) presented an 

 appearance analogous in histological structure to early cirrhosis as 

 seen in man, differing only in that the new connective tissue sur- 

 rounded the island of liver tissue persisting about the portal spaces, 

 instead of having a distinctly perilobular arrangement. Macro- 

 scopically, this liver was much firmer than normal, deeply bile 

 stained, and had a finely granular surface. Thus we have a form 

 of experimental cirrhosis affecting the liver in a diffuse but uni- 

 form manner, and more typical than any previously described in 

 the literature. 



The observations thus briefly outlined, while of importance in 

 explaining the histogenesis of cirrhosis, and incidentally of various 

 processes of repair in liver tissue, do not aid in the elucidation of 

 the etiology of cirrhosis in man, nor do they explain the peculiar 

 arrangement of the connective tissue in human cirrhosis. They 

 demonstrate, on the other hand, however, that cirrhosis may 

 follow extensive primary destructive lesions, a view not yet fully 

 accepted, and thus support the contention of Kretz that cirrhosis 

 is essentially the result of a series of repair processes following 

 repeated injuries of liver parenchyma. 



The earlier lesions closely resemble acute yellow atrophy of 

 the liver in man and appear to be of considerable importance in 

 explaining the pathogenesis of this process. 



38 (84). "Experimental arteriosclerosis": RICHARD M. 

 PEARCE and E. MOD. STANTON. (Presented by J. E. 



Sweet.) 



Within the past two years several French and German writers 

 (Josue, Erb and others) have described under the various names 

 of calcification, atheroma or arteriosclerosis, a lesion of the aorta 

 of rabbits produced by the intravenous injection of adrenalin. 



