36 Society for Experimental Biology and Medicine. 



and allyl alcohol), is chiefly due to the presence of such a group, 

 experiments were made (in Professor Ehrlich's laboratory) to 

 determine whether this is the case with quinin. A number of 

 derivatives in which the vinyl union was broken by the addition 

 of H (hydroquinin), or of O and OH (oxyhydroquinin), or of H 

 and CI (hydrochlorquinin), were tested as to their toxicity upon 

 various mammals and certain infusoria. The experiments showed 

 that the presence of the vinyl group in quinin is without special 

 significance as far as toxicity is concerned, the first two of the new 

 compounds being about as poisonous as quinin itself. The results 

 of the experiments with hydrochlorquinin are of special interest ; 

 these showed that the addition of H and CI decreases the toxicity 

 for mammals, while increasing it for infusoria. Thus the amount 

 of hydrochlorquinin required to kill mice was two and a half times 

 as much as that of quinin, while the former substance is distinctly 

 more poisonous to certain infusoria than the latter. It is possible 

 that hydrochlorquinin (or similar compounds) will be found to be 

 more effective in the treatment of malaria than is quinin, and further 

 work along these lines may result in the discovery of quinin 

 derivatives which will be of use in certain diseases, caused by 

 protozoa, in which quinin is of little value. Further experiments 

 are in progress. 



35. " Report on the metabolism of a case of diabetes mel- 

 litus": ARTHUR R. MANDEL and GRAHAM LUSK. 



The case was in a young man, whose urine contained no 

 albumin, little ammonia, only a small amount of aceton, and 

 no /?-oxybutyric acid. All these symptoms are said to justify a 

 favorable prognosis. The patient was put on three different diets 

 for three successive periods : Diet I. — Rich cream, oatmeal, 

 meat, eggs, butter. Diet II. — Same as I, with 100 grams of 

 levulose. Diet III. — Rich cream, meat, and eggs. The oat- 

 meal was used on account of the favorable results obtained by 

 von Noorden. 



Diet III was practically a meat-fat diet. Upon this diet the 

 polyuria decreased and the sugar fell from 8% to 4%, both 

 of which phenomena would be favorably interpreted by the clin- 

 ician. But on calculating the ratio between sugar and nitrogen 



