Scientific Proceedings. 



4i 





Extract. 1 



Phosphorus. Lecithin. 



Lecithin. 





$ of dry 



$ of the Jf of the 



"jo of dry 





organ. 



extract. extract. 



organ. 









Human Kidneys. 





I 



. . . II.42 



2. 1 1 



55 07 



6.29 f 





I2.48 



2.00 



52.03 



6.49 {; 



II , . 



. . . 11.44 



1.35 



35.14 



4.02 



XI . . . 



. . . I5.4O 



1. 18 



30.84 



4.76 f 







1.19 



31.09 



4.80 L 









Beef Kidneys. 





II . . . 





2.IO 



54-64 



8.21 









Dog Kidneys. 





I . . . 



• • • 14-93 



2.O4 



53-29 



7-95 









Rabbit Kidneys. 





I 



• • . 16.59 



2-53 



66.06 



10.96 2 



Autopsy Report. 



Cause 



of 

 death. 



Weight 



of 

 kidney. 

 Grams. 



Tuberculosis. 200 



40. "On the phloridzin test in Bright's disease ": PHCEBUS A. 

 LEVENE and LYMAN B. STOOKEY. 



Investigation of the action of phloridzin in Bright's disease has 

 a theoretical as well as a practical interest. The mechanism of 

 kidney diabetes is as yet imperfectly understood. The original 

 idea that it was due to a change in the permeability of the kidney 

 epithelium has gradually lost support, and instead there is a grow- 

 ing belief in the hypothesis that, in kidney diabetes, the sugar 

 owes its origin to an exaggerated katabolic condition of the kidney. 

 This view was first expressed by Dr. Levene in 1894. In 

 support of this theory, evidence was brought forward to show that 

 in animals with injured kidneys, phloridzin fails to bring about 

 glycosuria, or causes it in less degree than in normal animals. 

 However, it is impossible to injure, by means of drugs or by me- 

 chanical interference, only one special part of the kidney. In the 

 course of Bright's disease there are known conditions under which 

 the involvement of either the epithelium or of the glomeruli pre- 

 dominates to a very great extent, and this, of course, enables one 

 to study the seat of the sugar formation within the kidney. The 

 observations of most authors tend to show that when the epithelium 

 of the kidney is injured, administration of phloridzin fails to cause 

 glycosuria or does so in very slight degree. 



The authors injected simultaneously phloridzin and methylene- 

 blue, and compared the course of the elimination of the dye with 



1 The author presented a large number of data. The table here given shows only 

 a few examples of the many results obtained. 



2 2.24% of the fresh kidney. 



