44 Society for Experimental Biology and Medicine. 



sixth periods, succeeded by a rise in the next period. In the second 

 experiment the rate of secretion remained practically steady during 

 the fifth, sixth, seventh, and eighth periods. In the third experi- 

 ment there was a variation, but the average rate of secretion was 

 about the same in the fifth, sixth, and seventh periods as in the 

 preceding experiments. It would seem, therefore, that the dimin- 

 ished secretion of bile following the intravenous injection of alcohol 

 may be due to the influence of that substance. 



A study of the effect of alcohol on biliary secretion after injec- 

 tion into the stomach was also begun. It would seem a priori, in 

 the light of recent investigations by Bayliss and Starling, Fleig, 

 and Henriot, on the relation of secretin to the secretion of bile, 

 that the author's method of administering alcohol ought to pro- 

 voke secretion of bile. In the few experiments the author has 

 made thus far, he has observed that when 60 fo alcohol was intro- 

 duced into the stomach, there was a slight, transitory increase of 

 biliary secretion. With 30 fo alcohol there was in some cases an 

 increase, in some a decrease of the secretion of bile as compared 

 with pre-alcoholic periods. At this stage of the work it would be 

 premature to form any conclusion regarding this point. Whether 

 this slight increase is due to increased gastric secretion and con- 

 sequent formation of secretin, or is reflex in nature, will next be 

 investigated. 



43. " The influence of repeated external hemorrhages on the 

 general composition of the blood " : GUSTAVE M. MEYER 

 and WILLIAM J. GlES. 



Various observers have noted the fact that the composition of 

 the blood changes after hemorrhage, but no systematic study has 

 been made of these modifications. The authors have begun such 

 an investigation for the purpose of establishing a more definite 

 basis for comparative blood analysis. They reported the results 

 of their observations on posthemorrhagic changes in the percentage 

 content of water, total solids, organic solids, and ash. Further 

 study is in progress. 



Healthy, well-nourished or fasting dogs in light morphin- 

 atropin narcosis were used, and quantities of blood ranging from 

 0.2 r fo to 1.0 Jo of body-weight were taken. These amounts were 

 drawn from the femoral artery, and approximately the same 



