54 



Scientific Proceedings (117). 



For newborn infants the corrected formula is as follows: 

 A = x H nh X 78.50, 



or 



log A = log W X .425 + log H X .725 + 1.895. 

 26 (1773) 



On the relation of blood-volume to the nutrition of the tissues. 



I. The effects of hemorrhage and intravenous injections of gum- 

 saline on the response to the administration of a 

 mixture of carbon dioxide and room air, 

 and of room air alone. 



By ROBERT GESELL, CHARLES S. CAPP and FREDERICK S. FOOTE. 



[From the Department of Physiology, University of 

 California, Berkeley, California.] 



At the last meeting of the American Physiological Society 

 some experiments were reported on the effects of hemorrhage on 

 the response to a gradual reduction in the percentage of oxygen 

 in the respired air. These experiments were performed on the 

 normal unanesthetized dog connected by means of a mask with 

 a rebreathing apparatus arranged to absorb the carbon dioxide 

 of the expired air as the oxygen was consumed. The purpose of 

 the experiments was to determine the detrimental effects of 

 hemorrhage and the subsequent effects of replacing the lost blood 

 with a gum-saline solution. 



We reasoned that if a normal percentage of hemoglobin and a 

 normal flow of blood are essential for a normal gaseous exchange, 

 that the response of an animal to a reduction in the percentage of 

 oxygen in the respired air would be altered by hemorrhage; and 

 further that if the intravenous injection of gum-saline accelerated 

 the volume-flow of blood out of proportion to the accompanying 

 dilution, the reduced tolerance to low pressures of oxygen would 

 be improved. 



To our surprise we were unable to detect, with the methods 

 employed, any decrease in tolerance after hemorrhage amounting 

 to 3 per cent, of the body weight. We do not attempt to definitely 

 explain these results as yet, but wish to point out a striking effect 



