8 4 



Scientific Proceedings (118). 



4. Intravascular clotting has not been observed after intra- 

 venous administration of pancreatic rennet. 



43 (1790) 



Observations on the excretion of sugar in the urine in 

 health and disease. 



By LUDWIG KAST and HILDA M. CROLL. 



[From the Department of Medicine and the Laboratory of Pathological 

 Chemistry, New York Post-Graduate Medical School and 

 Hospital, New York City.] 



The amount of sugar in the twenty-four-hour urine specimens 

 has been determined by the new acetone-picric acid method of 

 Benedict and Osterberg. 1 It was found that a diet rich in carbo- 

 hydrate increases the amount of sugar excreted over that on a 

 low carbohydrate diet. This method also demonstrated the in- 

 crease in hourly sugar excretion after meals and after glucose 

 ingestion. In four normal adults studied, the average amount of 

 reducing sugar excreted daily was between 0.59 and 1. 14 grams. 

 In ten children from 2.5 to 9 years of age, representing a variety 

 of pathological conditions, the average range was from 0.12 to 

 0.43 gram sugar daily. To cite a few of the 116 hospital cases 

 studied, in 20 patients diagnosed as neurasthenics, on the average 

 between 0.42 and 1.24 grams sugar were excreted daily; in hyper- 

 thyroidism the average range was between 0.46 and 0.98 grams; 

 in one case of hypothyroidism an average of 0.40 gram sugar was 

 excreted; in nephritis 0.41 to 0.89 grams, in hypertension 0.44 

 to 1. 12 grams, in arthritis 0.44 to 1.39 grams, and in various 

 cardiac disturbances 0.51 to 1.39 grams on the average were 

 excreted daily. It appears, therefore, that in the diseases studied, 

 when the patients are on ordinary diets, there is no striking 

 increase nor decrease over normal urinary excretion. In diabetes 

 alone there is an increase, although when by dietary regulation 

 the patient is rendered "sugar free" the amount of sugar excreted 

 is practically normal. 



1 Benedict, S. R., and Osterberg, E., J. Biol. Chem., 1921, xlviii, 51. 



