Micro-manipulation and Micro-injection. 85 



44 (i79i) 



Isopropyl alcohol, a convenient laboratory anesthetic for cats. 



By DAVID I. MACHT. 



[From the Pharmacological Laboratory, Johns Hopkins University, 



Baltimore, Md.] 



In connection with a comparative study of normal and second- 

 ary alcohols the author had occasion to inquire into their com- 

 parative narcotic properties. It was noted that when a suitable 

 dose of isopropyl alcohol, a drug which is comparatively cheap, 

 is administered to cats by the stomach tube, a general anesthesia 

 is produced lasting for many hours and indeed in some cases for 

 several days. In order to use this drug as an anesthetic for cats, 

 the animals must first be completely anesthetized with ether, a 

 stomach tube is then passed and a dose of isopropyl alcohol from 

 5 to 5}4 c.c. per kilo weight of the animal is introduced into the 

 stomach together with two or three times its volume of water. 

 The stomach must be empty before the administration of the drug. 

 The brief-lasting stage of ether isopropylol anesthesia is quickly 

 followed by a complete narcosis, produced and maintained by the 

 isopropyl alcohol alone. Indeed it is usually not necessary to 

 take the cats off the table after the administration of the drug by 

 stomach tube. The blood pressure curve obtained with such 

 animals is remarkably high and the circulation is certainly much 

 less depressed than by certain chlorinated hypnotics which have 

 been used as anesthetics for cats. The effect on the respiration 

 in larger doses than above is more depressant but when the proper 

 dose is administered the animals continue to live with very good 

 circulation and satisfactory respiration for many hours. 



45 (1792) 



Apparatus for micro-manipulation and micro-injection. 



By ROBERT CHAMBERS. 



[From the Department of Anatomy, Cornell University Medical 

 College, New York City.] 



This apparatus is designed for the purpose of dissecting living 

 cells or injecting substances into them, and for isolating micro- 



