94 



Scientific Proceedings (118). 



adrenalin will cause a complete discharge of all the glycogen from 

 the muscle cells. 



In a third series of experiments, diabetic dogs were rendered 

 glycogen free as in the second series. They were then given 

 substances like glycocoll and alanin, propionic and lactic acids, 

 all of which are known to be converted quantitatively into glucose. 

 Not in one single instance was the glucose elimination from the 

 adrenalinized animals in any way comparable to the amounts 

 that are excreted by animals not treated with adrenalin. In other 

 words, either there is interference with sugar formation in the 

 absence of the "residual" glycogen or the glucose that is formed 

 from glucogenetic substances is utilized by these cells, and not 

 excreted in the urine. 



Table II is illustrative of this point. 



TABLE II. 



Influence of Deglycogenization on Extra Glucose Formation 

 from Lactic and Propionic Acids. 



Experiment Q2. Phlorhizittized Dog. Twelve Hour Periods. 



Period. 



Weight 

 in Kg. 



N. 



G. 



G : N. 



Extra 

 Glucose. 



Remarks. 



I 



13-68 



2-34 



20.54 



8.78 





First day of phlorhizin glu- 















cosuria. 



II 





4.29 



42.52 



9.92 





6 mg. adrenalin injected. 



Ill 



13-23 



6.77 



21.86 



3-08 





6 mg. adrenalin injected. 



IV 





6.66 



18.66 



2.80 







V 



12.83 



7.29 



20.59 



2.83 







VI 





6.04 



22.40 



3-71 



4.28 



9.0 gms. of lactic acid as 















sodium salt dissolved in 















24 c.c. water given sub- 















cutaneously. 



VII 



12.20 



5.62 



17.97 



3-20 







VIII 





6.47 



20.70 



3-20 







IX 



II-95 



5-79 



17.58 



3.04 







X 





4.88 



14.72 



302 







XI 



11.48 



4.80 



18.38 



383 



2.75 



7.4 gms. propionic acid as 















sodium salt dissolved in 















20 c.c. water given sub- 















cutaneously. 



XII 





4.41 



15.40 



3-50 







XIII 





4-51 



15.16 



3-36 







At end of period XIII, ether anesthesia, animal bled to death. Glycogen in 

 muscles 0.039, 0.038 per cent. 



In this experiment the giving of adrenalin during period II is 

 followed by a sweeping out of all the residual glycogen, as is 



