Concerning Antiketogenesis. 



97 



which was kept for five days after deglycogenization 0.069 gram 

 of glycogen was found per 100 grams of muscle. 



These experiments prove that fasting diabetic dogs, even after 

 they have been completely deglycogenized, possess the power of 

 glycogen formation. Glucogenetic substances therefore can well 

 be administered to animals without giving rise to extra glucose in 

 the urine. 



Conclusion. 



I. Diabetic dogs contain glycogen in their muscles to the 

 extent of 0.150 per cent, even after seven days of fasting and 

 diabetes; residual glycogen. 



II. This glycogen can be completely driven out by means of 

 adrenalin. 



III. Deglycogenized diabetic animals even during a period of 

 prolonged fasting and diabetes are capable of reforming their lost 

 residual glycogen. 



IV. Failure on the part of an animal to show extra glucose 

 elimination during the period of deglycogenization does not mean 

 that the substance is not glucogenetic. 



V. The conclusions of Sansum and Woodyatt that acetalde- 

 hyde is not glucogenetic nor antiketogenetic are objected to as 

 invalid. 



50 (1797) 

 Concerning antiketogenesis. 



By A. I. RINGER. 



[From the Montefiore Hospital, New York City.] 



It is a well-known fact that the withdrawal of carbohydrates 

 from the diet of normal individuals is followed by the appearance 

 of ketone bodies in the urine. Individuals that have interference 

 with their power to utilize carbohydrates, as diabetics, develop 

 degrees of ketonuria that are proportional to the severity of the 

 disturbances in their carbohydrate metabolism. It is also estab- 

 lished definitely that these ketone bodies are formed normally in 

 the intermediary metabolism of fat and of certain amino acids, 

 and that with the oxidation of carbohydrates the ketone bodies 

 suffer oxidation. The carbohydrates therefore are known as anti- 

 ketogenetic. 



