i88 



Scientific Proceedings (120). 



sufficed to cure the ophthalmia but a larger quantity appeared to 

 be necessary to secure restoration of growth. Inasmuch as 

 Cooper 4 has reported the presence of vitamin A in orange peel, 

 special precaution was taken in our work to avoid contamination 

 of the juice with the latter. 



Owing to the comparative richness of orange juice in carbo- 

 hydrates, so that 10 c.c. represent a not inconsiderable intake of 

 non-protein calories, it is important that the proportion of protein 

 and essential salts in the rest of the ration be large enough to 

 promote growth at the normal rate. The data now available 

 from animal feeding experiments indicate the presence of vitamins 

 A, B, and C in the orange and the possibility of conserving them, 

 in part at least, undeteriorated by suitable processes of desiccation. 

 With respect to the proportions of these different vitamins present 

 our experiments indicate that volume for volume orange juice is as 

 rich as is milk in vitamin B, but somewhat less rich in vitamin A. 

 According to the data furnished by Givens and McClugage, 5 orange 

 juice is much richer than milk in vitamin C. 



88 (1835) 



Studies in experimental plethora in dogs and rabbits. 



By E. B. KRUMBHAAR and A. CHANUTIN. 



[From the John Herr Musser Department oj Research Medicine, 

 University of Pennsylvania, and the Laboratories of the 

 Philadelphia General Hospital, Philadelphia, Pa.} 



The object of the present communication is to present the 

 functional changes produced by repeated transfusions in the 

 blood-making and blood-destroying apparatus, and in metabolism, 

 and the structural changes in the viscera of dogs and rabbits. 

 In an attempt to throw further light on the relation of the spleen 

 to blood formation and blood destruction, we first studied the 

 effect of splenectomy in artificial plethora, and tried to find 

 evidence of increased enzyme action in the spleen removed at a 

 time when blood was being destroyed in greatly increased quanti- 

 ties. Not only were these efforts barren of results, but it was 



* Cooper, Proc. Soc. Exper. Biol, and Med.. 192 1, xviii, 243. 

 6 Givens and McClugage, Am. J. Dis. Child., 1919, xviii, 30. 



