Scientific Proceedings (120). 



In splenectomized animals the tendency to "plethoric anemia" 

 is much more apparent, although a direct connection between the 

 two events has not been established. 



In splenectomized animals pigment-bearing phagocytes are 

 especially prominent in the liver, although lymphnodes and bone 

 marrow apparently share in the extra work caused by the absence 

 of the spleen. Lymphnodes with some of the characteristics of 

 hemolymphnodes have been found in various localities in all 

 animals that had been made plethoric. 



In rabbits, blood pigment is deposited in the organs in large 

 amounts, but the picture and the experiment has in our hands 

 been constantly complicated by early fatal intravascular aggluti- 

 nation and thrombosis. In the rabbit, as in human hemochroma- 

 tosis, the pigment is found in 2 forms: Hemosiderin granules, and 

 smaller, dark spicules that do not react to the usual iron stains 

 (probably hemofuscin). The latter pigment is also found seeded 

 through the cells of the liver parenchyma. 



89 (1836) 



Changes in total peripheral resistance during experimental shock. 



By DONALD D. FORWARD and LOUIS J. PERME. 



[From the Physiological Laborator y of Western Reserve 

 University Medical School, Cleveland, Ohio.] 



The question as to whether the peripheral resistance is increased 

 or decreased in experimental shock has been submitted to repeated 

 investigations, but with contradictory results. 1 On the basis of 

 changing contours of the aortic pressure curves found during the 

 course of experimental shock, Wiggers 1 came to the conclusion 

 that a reduced peripheral resistance obtained early in shock. 

 Apparently contradictory results were however soon reported by 

 Erlanger, Gasser and Gesell 1 who employed, in modified form, 

 the procedure described by Bartlett 2 — a method which measures 

 essentially the rate of saline inflow into the main artery of an 

 organ or limb temporarily isolated from the rest of the arterial 



1 For recent review of literature cf. Wiggers, Amer. J. Physiol., 1918, xlvii, 498; 

 Erlanger, Gesell and Gasser, Amer. J. Physiol., 1919, xlix, 103. 

 7 Bartlett, Jour. Exp. Med., 1912, xv, 415. 



