192 



Scientific Proceedings (120). 



Shortly after opening the abdomen and beginning of the 

 gastric manipulation the total resistance showed pronounced 

 changes. In a few cases (especially those in which there had 

 been a previous hemorrhage), the total resistance was found to 

 increase, for a time. The optical curves in such cases showed no 

 essential variations, however. In the majority of cases, however, 

 the total resistance as measured by the Cope method decreased 

 at once and the optical curves showed typical changes interpreted 

 as characteristic of low peripheral resistance. 



During the progressive stages of shock, i.e., where mean 

 arterial pressure begins to fall, wide fluctuations in resistance were 

 found by the Cope method, confirming observations of Erlanger, 

 Gasser and Gesell. In those experiments, however, in which the 

 total resistance was initially decreased, it continued below normal. 



We believe, therefore, that direct proof has been supplied that 

 the early changes in contours of the arterial pressure curves during 

 shock are associated with a reduced peripheral resistance. Taken 

 in conjunction with the observations of Erlanger, Gesell and 

 Gasser that the arterioles at this time are constricted these results 

 lend support to the idea that the point of vaso-relaxation in 

 shock is in the capillaries rather than the arterioles. 



90 (1837) 



Experimental plumbism: therapeutic efficiency of some agents 

 and comparative toxicity of other metals. 1 



By P. J. HANZLIK, MARY MclNTYRE and ELIZABETH PRESHO. 



[From the Departments of Pharmacology, Leland Stanford 

 Junior University, San Francisco, CaL, and Western 

 Reserve University, Cleveland, Ohio.] 



Experimental chronic lead poisoning was produced by feeding 

 metallic lead in the form of bullets to pigeons. The symptoms 

 are characterized by a prompt loss of body weight and appetite, 

 gradual depression, loss of equilibrium, diarrhea, increased crop 

 peristalsis with regurgitation of contents, wing drop (anatomically 

 corresponding to drop-wrist in man), paralysis of legs, marked 

 emaciation and death at the end of 21 days (mean). At autopsy, 



