Ligation of the Thyroid Arteries. 



209 



96 (1843) 



Further studies on ligation of the thyroid arteries in depancreatized 



diabetic dogs. 



By G. A. FRIEDMAN and J. GOTTESMAN. 



[From the Department oj Clinical Pathology, College of Physicians 

 and Surgeons, Columbia University, New York City.] 



The experiments described in this and in the following paper 

 were conducted during the year of 192 1. 37 dogs were depan- 

 creatized; 9 did not develop glycosuria although in some of them 

 repeated pancreatectomies were performed at various intervals. 

 3 of the animals showed a transitory glycosuria. 25 dogs became 

 persistently glycosuric ; 9 of these dogs died of various causes. 

 Ligations of all of the thyroid arteries were done in 8 of 16 gly- 

 cosuric dogs who survived the pancreatectomies, in about 4 to 7 

 days after complete or almost complete removal of the pancreas. 

 In one dog the thyroid arteries were ligated in two sittings: first 

 both arteries on the right side and s^ven days later the arteries on 

 the opposite side. This dog died from tetany on the day following 

 the second ligation. 3 of those who were completely ligated died 

 without demonstrable causes from 1 to 2 days after ligation. 



Thus in only 5 dogs could the effect of complete ligation be 

 studied and only in one the effect of partial ligation. 



The great losses in body weight which usually follow de- 

 pancreatizations were not checked by the ligations. 



Some interesting points, however, were brought out from the 

 study sufficient to warrant a report. As far as we know there is 

 no literature pertaining to ligations of thyroid vessels in depan- 

 creatized dogs. 



In a previous paper 1 we referred to an experiment with dog 

 No. 106 who was completely depancreatized. His urine on daily 

 examinations showed from 5 per cent, to 6 per cent, sugar. On the 

 fourth day all thyroid arteries of the animal were ligated. He 

 became sugar-free five days after the operation, and he remained 



1 Friedman, G. A., and Gottesman, J., Proceed. Soc. Exp. Biol, and Med., 

 1921, xviii, 281. 



