216 



Scientific Proceedings (121). 



worked with 3 dogs and the latter with two. In Allen's 1 experi- 

 ments (191 3) w r ith diabetic dogs the thyroidectomies were in- 

 complete. Eppinger, 2 Falta and Rudinger (1908) removed first 

 the thyroid and later the pancreas in two dogs and they did a 

 simultaneous thyroidectomy and pancreatectomy in one dog. 

 Eppinger 3 and his associates (1909) also studied the relation of 

 parathyroid insufficiency to the metabolism in diabetic dogs by 

 removing simultaneously the pancreas with three parathyroids in 

 two animals. 



Lorand has asserted that removal of the thyroid sparing the 

 parathyroids is followed by the disappearance of sugar from the 

 urine in two days in depancreatized dogs. In one of McCallum's 

 dogs the glycosuria ceased after removal of the thyroid; in the 

 other one it greatly diminished. In one of the experiments of 

 McCallum two parathyroids were spared; in the other all were 

 left in situ. A marked diminution of sugar after thyroidectomy 

 w r as also reported by Eppinger. In all these experiments, blood- 

 sugar estimates were not made. The duration of life in the animals 

 of Lorand and McCallum was from one to three days after com- 

 plete removal of the thyroid even if the parathyroids were left 

 in situ. Three of our diabetic dogs in w T hom thyroidectomy with 

 partial parathyroidectomy was performed 3 to 4 days after pan- 

 createctomy, died from 1 to 3 days after the operation. From 

 two of these dogs no urine was obtained, and in one dog the gly- 

 cosuria persisted on the day following the removal of the thyroid. 



We may mention here two clinical cases cited by Rohdenburg. 4 

 One patient was diabetic and later developed exophthalmic goitre. 

 A portion of his thyroid was removed and he remained perma- 

 nently sugar-free. The other patient had exophthalmic goitre for 

 which a portion of the thyroid was removed. Several years later 

 he developed glycosuria. The glycosuria in this case disappeared 

 after removal of more of the thyroid gland. 



Wedecided thai it would be a better procedure to first partially 

 ligate the thyroid arteries and follow this operation on a later 

 date by partial thyroidectomy, or if possible by thyroidectomy 



1 Allen, Frederick M., 1913, p. 848. 



7 Eppinger, Falta and Rudinger, Ztschr. f. Klin. Med., 1908, lxvi, 1. 



8 Eppinger, Falta and Rudinger, Zt$chr. f. Klin. Med., 1909, 380. 

 * Rohdenburg, G. L., "Endocrinology," 1920, iv, 63. 



