Pancreatic Diabetes in Dogs. 



217 



alone. One may occasionally succeed in sparing all parathyroids 

 while removing the thyroid especially in larger dogs. 



In a previous 1 paper we referred to an experiment with dog 

 No. 100, who became diabetic after removal of a little over one 

 half of his pancreas. Such rare results are occasionally reported 

 in the literature. As the external secretory apparatus of the 

 pancreas was not much affected, but continued functioning, we 

 believe that truly by chance, we produced in this animal a condi- 

 tion which came very close to human diabetes. Inasmuch as this 

 experiment is a singular one in literature we shall briefly refer 

 to it. 



Seven days after the dog had from 2 to 3 per cent, sugar in his 

 urine, both inferior thyroid arteries were ligated. The glycosuria 

 persisted on daily examinations. Seven days later both lobes of 

 the thyroid were removed and we succeeded in sparing all of his 

 parathyroids. There was not a trace of sugar in his urine on the 

 day following thyroidectomy and the urine remained sugar-free 

 for 108 days, although eleven days after removal of the thyroid, 

 additional pancreatic tissue was removed, and ninety-three days 

 after the second pancreatectomy the last remnant of the gland 

 was taken out. The animal was sugar-free four days after the 

 third pancreatectomy. He died on the fifth day from prolapse 

 of the intestines, which was probably brought about by the three 

 laparotomies. 



The dog's condition was excellent; ate well until the day of 

 the accident. He did not show any signs of myxedema during 

 the time of observation and while his original weight was 14 kilos 

 his weight the day before death was 15.9 kilos, or a gain of 1.9 

 kilos. His blood sugar remained normal and 14 days after re- 

 moval of the thyroid his sugar tolerance was about 10 grams per 

 kilogram of body weight. Fig. 1 shows a photograph of the dog 

 93 days after removal of his thyroid. 



Conditions become quite different when one does not succeed 

 in imitating human diabetes and when sparing all the parathyroids 

 in doing a parathyroidectomy is impossible. Infection also 

 changes the situation. It is our impression that diabetic dogs 



1 Friedman, G. A., and Gottesman, J., Proceed. Soc. Exp. Biol, and Med., 

 1921, xviii, 281. 



