Anaphylactoid Phenomena. 



303 



cats in histamin shock. Histamin also causes agglutination of 

 human, avian, guinea pig, dog and cat red blood corpuscles "in 

 vitro," which is consistent with the formation of thrombi and 

 emboli "in vivo." 



The following agents, caramel (50 per cent.), cane sugar, 

 casein, calcium lactate, lutein extract, horse serum, colloidal gold 

 (sensitive), colloidal gold (protected) and colloidal sulphur 

 (saturated), did not cause anaphylactoid symptoms. Pulmonary 

 thrombi were not demonstrable after cane sugar, sodium chloride, 

 casein, calcium lactate, horse serum and colloidal gold (sensitive). 



Cane sugar and sodium chloride (hypertonic solutions) have 

 been advocated and used for the prevention and treatment of 

 anaphylactoid symptoms. The rationale of this is not understood, 

 but is alleged to be concerned with alterations in the physical- 

 chemical properties of the colloids of the blood. Accordingly, 

 attempts were made to treat anaphylactoid symptoms produced by 

 kaolin, histamin, acacia, and beef serum by preliminary injections 

 of 50 per cent, cane sugar and of 10 per cent, sodium chloride. 

 However, the results obtained were uniformly negative as to 

 prevention of symptoms and thrombi. 



Intraperitoneal injections were made with the following agents, 

 allowing at least one hour after administration for development 

 of symptoms; agar sol-gel, toxified agar, horse serum, beef serum, 

 lung extract, histamin, colloidal gold (sensitive), colloidal sulphur 

 (saturated), Congo red, glacial acetic acid and copper sulphate. 

 With the exception of copper sulphate, the results were uniformly 

 negative. The intraperitoneal injection of copper sulphate in 

 the same dosage as was used intravenously, caused anaphylactoid 

 symptoms and death in 40 minutes. Pulmonary thrombi were 

 definitely present after intraperitoneal injection of histamin only. 



137 (1884) 



Urinary excretion of salicyl after the administration of salicylate 

 and salicyl esters. 



By P. J. HANZLIK, FLOYD DE EDS and ELIZABETH PRESHO. 



[From the Department of Pharmacology, Leland Stanford Junior 

 University, San Francisco, CaL] 



Using sodium salicylate as a control, the excretion of methyl 



