304 



Society Proceedings (122). 



salicylate, acetylsalicylic acid and salicylosalicylic acid (diplosal) 

 was compared in each of three human individuals. Small doses 

 of 0.5 gm. to 1 gm. were used. The mean total excretion of sodium 

 salicylate was 80 per cent., which agrees with the results obtained 

 with very large doses (12 gms.) previously reported. On the 

 other hand, the mean total excretion of salicyl after the administra- 

 tion of the salicyl esters was distinctly less, namely, 60 per cent. 

 Special treatment of the urines for detection and estimation of the 

 undecomposed esters gave contradictory results. Unchanged 

 esters appeared to be present to a small extent only in some urines, 

 absent in other urines. Ethereal extractives of the urines after 

 the administration of methyl salicylate possessed a fruity odor, 

 indicating the presence of the unchanged ester. Larger doses of 

 the esters may give more conclusive evidences along this line. 

 Since all urines were collected until excretion of salicyl was com- 

 pleted, the salicyl unaccounted for appears to have been destroyed, 

 and this is confirmative of previous results with large doses of 

 sodium salicylate. The mean duration of excretion of sodium 

 salicylate and the esters was practically the same, namely, about 

 48 hours; only the methyl salicylate showing a tendency to some- 

 what more prolonged excretion (55 hours). 



138 (1885) 



The effect of the administration of salvarsan in combination with 

 various colloid substances on its toxicity. 



By JEAN OLIVER and SO SABRO YAMADA 



[From the Department of Pathology of the School of Medicine, 

 Leland Stanford Junior University, San Francisco, Cal.] 



In some unpublished articles it has been shown that the ill 

 effects following salvarsan administration may be divided into 

 two types; first, an immediate reaction from which the animal 

 dies suddenly in a convulsive seizure as a result of embolism of 

 its agglutinated red cells, and second, a late death occurring in 

 from two days to as many weeks, which is the result of degenera- 

 tive lesions in the kidneys and liver. As the former has been 



