332 



Scientific Proceedings (123). 



cent, of the anhydrous salt, euglobulin and pseudoglobulin L 

 After the ingestion of colostrum containing these globulins rela- 

 tively large quantities of the proteins appeared in the serum. 

 Subsequent data have shown that there is evidence of absorption 

 of the proteins within 3 to 4 hours and a very marked accumula- 

 tion of the proteins 6 hours after receiving colostrum. Further- 

 more, we have one case in which both the agglutinins (Little) and 

 the globulins decrease in amount with increasing age. The time 

 and conditions of the formation of the globulins is being studied. 

 The demonstration that the agglutinins are associated with the 

 globulin fractions of the proteins of blood and colostrum and 

 their absorption by young animals tends to support the idea of 

 direct absorption into the blood of newborn calves of certain 

 protein fractions present in colostrum. 



The conception of a direct absorption of agglutinins and pro- 

 tein by the young animals based upon biological reactions has 

 appeared repeatedly in the literature relating to the transmission 

 of immunity. The absence of a substance reacting with colostrum 

 antiserum in the blood of newborn calves which is acquired after 

 the ingestion of colostrum has been demonstrated by Langer. 1 

 The acquirement of relatively large quantities of particular pro- 

 tein fractions by the newborn and the association of the agglu- 

 tinins with these fractions we believe to be a new demonstration. 



156 (1903) 



The effect of saline purgatives on the absorption of other drugs. 



By DAVID L MACHT and E. M. FINESILVER. 



[From the Pharmacological Laboratory, Johns Hopkins University, 



Baltimore, Md. 



It is well known that the pharmacodynamics of saline purga- 

 tives consists chiefly in the poor absorbability of certain ions 

 such as those of magnesium, sulphate, phosphate, etc., and the 

 accumulation of fluid in the intestinal canal through the osmotic 

 action of the unabsorbed salt which, instead of being absorbed, 

 actually draws fluid into the intestinal lumen. This peculiar 



1 Langer, Verhandl. d. Gesellsch. f. Kinderheilk., 1907. xxiv, 70. 



