The Bile Factor in Pancreatitis. 



353 



purate was excreted more slowly than sodium benzoate in the 

 mammal. 



This phenomenenon is of particular interest because Bunge 

 and Schmiedeberg 1 demonstrated that hippuric acid is synthe- 

 sized from benzoic acid and glycocoll in the kidney, while hippuric 

 acid merely passes through it. It is interesting to speculate upon 

 the possibility that the process of synthesis may bring about or 

 be associated with a local vasodilation. 



Among other drugs studied, nitroglycerine, one five-thousand 

 solution, theobromine, one per cent, solution, and sodium indigo 

 sulphonate, one per cent, solution, increased the glomerular circu- 

 lation in a similar manner; and indigo sulphonate definitely stained 

 the glomerular capsule blue. This shows that sodium indigo sul- 

 phonate is excreted through the glomeruli as well as through the 

 tubules. Heidenhain 2 had demonstrated the excretion of this 

 substance through the tubules but not through the glomeruli. 3 



170 (1917) 

 The bile factor in pancreatitis. 



By FRANK C. MANN and ALFRED S. GIORDANO. 



[From the Division of Experimental Surgery and Pathology, Uni- 

 versity of Minnesota, Rochester, Minnesota.] 



We have investigated the bile factor in pancreatitis from two 

 chief aspects, the anatomic and the experimental. 



Anatomically, two mechanisms have been suggested whereby 

 bile can be passed into the pancreatic duct. One is based on the 

 possibility that an obstruction could occur at the exit of the com- 

 mon bile duct in a manner to convert the two ducts into a contin- 

 uous channel. We studied the relationship of the common bile 

 duct to the pancreatic duct and their mode of entrance into the 



1 Bunge, G. and Schmiedeberg, O., Arch, exper. Path. u. Pharmacol., 1876, vi, 



233. 



2 Heidenhain, Pfliiger's Arch. f. d. ges. Physiol., 1874, ix, 1; Hermann's Hand- 

 buch der Physiol., 1883, v, 279-373. 



3 We desire to thank Dr. F. B. Kingsbury for furnishing the sodium hippurate 

 and for suggesting this phase of the problem. 



