388 



Scientific Proceedings (124). 



removal of the stellate ganglia and cutting the vagi in the neck, 

 in the cat. 



The investigation is being continued. 



189 (1936) 



The effect of thyroidectomy in two sittings upon depancreatized, 

 non-glycosuric, but hyperglycemic dogs. 



By G. A. FRIEDMAN and J. GOTTESMAN. 



[From the Department of Clinical Pathology, College of Physicians 

 and Surgeons, Columbia University, New York City.] 



Dogs almost always show an increase in bloodsugar contents 

 from removal of comparatively small amounts of pancreatic tissue. 

 Of six dogs in whom hyperglycemia without glycosuria became 

 manifest after partial pancreatectomy, in two the right lobe was 

 removed first and at a later date lobectomy on the other side 

 followed. In three hyperglycemic dogs the right lobe was com- 

 pletely removed, but while performing the lobectomy on the left 

 side a tiny piece of thyroid tissue was left in connection with the su- 

 perior parathyroid. In one dog both lobes were removed at the 

 same time. In all of them three parathyroids were left in situ. 



In the completely thyroidectomized diabetic dog the blood-- 

 sugar became normal on the day following the last operation. On 

 the third day tetany developed which was kept in check by intra- 

 venous injections of calcium lactate. The bloodsugar had re- 

 mained normal. On the fifth day a severe attack of tetany de- 

 veloped. Calcium lactate injections were not tried and the 

 animal died. 



The results of these experiments are in accord with those pre- 

 viously reported: one-sided lobectomy does not check hypergly- 

 cemia, neither does partial ligation in glycosuric dogs. Complete 

 thyroidectomy in the hyperglycemic dog brought the bloodsugar 

 to normal as the same procedure in glycosuric dogs when tetany 

 did not ensue or when it was checked by calcium lactate. 



Some new points were brought out in those dogs in whom at a 

 second lobectomy a minute fragment of thyroid tissue was left. 



