400 



Scientific Proceedings (124). 



In all of the cases studied there was no significant change in 

 the white blood-cell counts. Judging from the percentages of 

 blood total solids, the increases in red blood cells were not due 

 to a concentration of the blood from loss of fluid. The color 

 index generally dropped early in the treatment with a gradual 

 rise later. A study of chemical blood and urine analyses in cer- 

 tain cases revealed no apparent effect of the germanium on the func- 

 tional activity of the kidneys. The periodic effect on the red-cell 

 count noted by Hammett and M tiller was also noted in this study. 



198 (1945) 

 Influence of ischemia on infection. 



By TORALD SOLLMANN and J. G. BRODY. 



[From the Department of Pharmacology of the Medical School of 

 Western Reserve University, Cleveland, Ohio.] 



The following experiments furnish a striking illustration, suit- 

 able for class-room demonstration, of the influence of temporary 

 ischemia on the local resistance to infection : 



Two or three slight cuts are made on the upper or middle third 

 of each ear of a rabbit, by closely clipping the hair from the dorsal 

 surface of the ear; lifting with forceps a small fold of the skin, and 

 snipping this fold away with scissors. This makes small wounds 

 of about 4 by 7 mm., usually without hemorrhage. The wounds 

 may then be smeared with active a gar-cultures of staphylococcus 

 or pyocyaneus; or they may be left without artificial infection. 

 Within a few minutes after making the wounds, 1 c.c. of epine- 

 phrin, 1 : 1000, is injected into the root of one ear, close to the 

 entrance of the vessels. This produces an intense ischemia of the 

 entire ear. persisting for several hours. 1 



From the following day, the two ears present a striking differ- 

 ence in appearance: The wounds on the normal ear show signs 

 of healing, even if they were severely infected. The wounds on 

 the ear that had been rendered anemic appear much more in- 

 flamed, and may be covered with pus, and a perforating ulcer 



1 Aucr and Meltzer, Proc. Soc.'Exper. Biol, and Med., 1916. xiv, 54. 



