The Synthesis of Bexzoyltaurin. 



403 



of healthy young guinea pigs. Such cystic conditions are, of 

 course, frequently found in normal stock but here especially in 

 old or unhealthy specimens. 



The changed nutritive conditions in the reproductive organs of 

 underfed animals cause circulatory congestion, and as was pointed 

 out in a previous communication 1 such conditions suppress the 

 cestrous changes and prevent ovulation in these animals. The 

 congestion and the high pressure resulting therefrom seem to favor 

 the proliferation of the epithelial lining of the epididymal tubules 

 located near one pole of the ovary, and the accumulation of fluid 

 within the lumen of the blind tubules. 



The malnutrition expresses itself first within the ovary by a 

 wholesale degeneration of developing follicles which seem to respond 

 most delicately to changes in nutritive conditions. The conges- 

 tion and follicular degeneration seem then to favor an over- 

 growth of the more resistant epididymal tubules which become 

 distended and crowd out the parenchymatous portion of the ovary. 



Uterine cysts seem to develop in the same way as those above 

 as a response to the congestion resulting from malnutrition. 

 The open mouths of the uterine glands make their cystic condi- 

 tion rare so that among hundreds of ovarian cysts of all sizes we 

 have observed only one perfectly typical case of uterine cyst. 



These experiments seem to indicate that ovarian and paro- 

 varian cysts represent growths of persistent embryonic tissue, 

 and that an accompanying congestion and high pressure are nec- 

 essary to the formation of typical cysts, and that these condi- 

 tions may result from disturbed nutrition as is demonstrated by 

 underfeeding the guinea pigs. 



From The Pacific Coast Branch. 

 201 (1948) 

 The synthesis of benzoyltaurin. 



By CARL L. A. SCHMIDT and W. E. SCOTT. 



[From the Department of Biochemistry and Pharmacology of the 

 University of California, Berkeley, Cal.] 



It appears to be a specific function of several of the amino 



1 G. N. Papanicolaou and C. R. Stockard, Proc. Soc. Exp. Biol, and Med., 

 1920, xvii, 143. 



