404 Scientific Proceedings (124). 



acids to combine with certain substances which the body is un- 

 able to oxidize. When benzoic acid and the numerous aromatic 

 substances which are converted into benzoic acid in the body are 

 ingested by man and certain other animals they are* eliminated 

 in the urine almost quantitatively as hippuric acid. Phenylacetic 

 acid is voided in the urine of the dog and of the rabbit conjugated 

 with glycocoll as phenaceturic acid 1 while in man it combines 

 with glutamine and appears in the urine as phenylacetylgluta- 

 mine. 2 The following also belong to the list of substances which 

 undergo conjugation with glycocoll in passing through the body: 

 furfurol 3 which in part is first oxidized to pyromucic acid and 

 excreted as pyromucuric acid and in part combines with acetic 

 acid and is eliminated as furfuracryluric acid, a-methylthiophene 4 

 which is oxidized to a-thiophenic acid and appears in the urine as 

 thiophenuric acid, and a-methyl pyridin (a-picolin) 5 which after 

 oxidation to a-pyridin carboxylic acid passes into the urine as 

 a-pyridinuric acid. The role which in animals is given to glyco- 

 coll is taken in birds by ornithin. 6 Ingestion of benzoic acid by 

 chickens leads to the appearance of ornithuric acid and similarly, 

 pyromucic acid is conjugated with ornithin to give pyromucinor- 

 nithuric acid. In certain instances the part of the conjugating 

 amino acid is taken by cystein 7 and by taurin. Halogen combina- 

 tions of benzol and naphthalin are linked in the body with cystein 

 and this substance, after acetylation of the amino group, appears 

 in the urine combined with glucuronic acid. In the bile of most 

 animals both glycocoll and taurin are found in combination with 



1 Salkowski, E., Z. physiol. Chem., 1885, ix, 229. 



2 Thierfelder, H., and Sherwin, C. P., Berichle, 1914, xlvii, 2630. Thierfelder, 

 H., and Sherwin, C. P., Z. physiol. Chem., 1915, xciv, X. Sherwin, C. P., Wolf, M., 

 and Wolf, W., J. Biol. Chem., 1919, xxxvii, 113. Shiple, G. J., and Sherwin, C. P., 

 J . Amer. Chem. Soc, 1922, xliv, 618. 



3 Jaffe, M., and Cohn, R., Berichle, 1887, xx, 231 1. 



4 Jaffe, M., and Levy, H., Berichle, 1888, xxi, 3458. 



6 Cohn, R., Z. physiol. Chem., 1893, xviii, 112. 



1 Jaffe, M., Berichle, 1877, x, 1925; 1878, xi, 406. Jaffe, M., and Cohn, R., 

 Berichle, 1888, xxi, 3461. Totani, G., Z. physiol. Chem., 1910, lxviii, 75. Suga, T., 

 Chem. Abslr., 192 1, xv, 881. 



7 Baumann, E., and Preusse, C, Berichle, 1879, xii, 806. Z. physiol. Chem., 

 1881, v, 309. Baumann, E., and Schmitz, P., Z. physiol. Chem., 1895, xx, 586. 

 Jait' , M . Berickte, 1897, xii, 1092. 



