Volumetric Study of Hypophysis Cerebri. 421 



physis (Nos. 21-66) is seen to have an especially small pars ner- 

 vosa (posterior lobe). The great size of the female hypophysis 

 is due to a large pars anterior. The hypopituitary case has a 

 hypophysis very similar in volumetric relations to the female. 

 The absence of data on the parenchyma of pars intermedia of the 

 female hypophysis is due to the fact that the cells of this portion 

 in this particular case were very few and the tissue not fresh 

 enough when fixed to be well differentiated by the stain. This 

 will have to be expected in a few cases since pars intermedia con- 

 stitutes such a small irregular part of the entire gland — a fact of 



Fig. 1. Diagram showing how the field is explored in making the differentia^ 

 count of cells in pars anterior. The solid circles represent the fields which are 

 actually used. 



some consequence in view of Bab's theory that the polyurea in 

 hypopituitarism is due to hyposecretion of the pars intermedia 

 and because in some of the lower forms this part of the hypophysis 

 is distinctly connected with pigmentation. The greatest error 

 will always be in connection with the juxtaneural portion ; but the 

 error can be decreased by placing this part of the gland under 

 higher magnification if that should be deemed necessary. 



In Table III is shown a typical cell count as obtained by the 

 method here outlined. 



