Alkaline Tide in Urine. 



429 



She does not show any ill effects as yet. Two adults, a boy 5 

 years old, and two dogs, fed milk of this cow the first week of the 

 experiment, developed diarrhea. Two dogs fed the milk the 

 second week did not show any ill effects. A two-day-old calf 

 began sucking this cow 15 days after the experiment was started. 

 He gained weight steadily and showed no apparent ill effects. 

 The calf was killed by bleeding from carotid at the age of 5 weeks. 

 Autopsy showed oedema of the perirenal fat and of the omentum. 

 In the peritoneal cavity, there was about 600 c.c. reddish liquid 

 that gelatinized on standing, similarly to the ascitic liquid found 

 in the pigs. All the other organs appeared normal. 



211 (1958) 



A comparison of the alkaline tide in urine with the results of 

 fractional gastric analysis. 



By ROGER S. HUBBARD and SAMUEL A. MUNFORD. 



[From the Clifton Springs Sanitarium, New York.] 



The fact that the acidity of the urine decreases after meals is 

 well known, and this decrease has been commonly attributed to 

 the secretion of hydrochloric acid by the stomach during the proc- 

 ess of digestion, but there are comparatively few experiments 

 recorded in which direct comparison between urine studies and 

 analyses of the acid content of the stomach by the newer methods 

 have been made. In the series of cases presented determinations 

 of hydrogen-ion concentration, titratable acidity, ammonia, and 

 in some instances, total nitrogen, were made on urine collected 

 at two-hour intervals through the day from patients who had been 

 studied for hyperacidity or anacidity of the stomach by the usual 

 method of fractional gastric analysis. Those cases which showed 

 free hydrochloric acid in the stomach showed the "alkaline tide" 

 in the morning, and usually in the afternoon as well, while the 

 cases which did not show hydrochloric acid, with one possible 

 exception, did not show the tide. 



The depth and duration of the alkaline tide did not correspond 

 with the relative amounts of hydrochloric acid found in the gas- 



