OliSERVATIONS ON THE CLINICAL ASPECTS OF HEMOLYSIS. 3 



2 (340) 



Further observations on the clinical aspects of hemolysis. 



By GEORGE W. CRILE. 



\_From iJic lAiboratorv of the Prwate Ward Sendee of Lakeside 

 Hospilal, Cle-relaiid, 0.~\ 



All cases of tuberculosis showed reverse hemolysis, /. e., 

 normal serum hemolyzed the patient's coipuscles. In all cases 

 serum heated to 55° C. for ten minutes prevented hemolysis. 

 Sudden chilling of the blood according to the method of Hoover 

 and Stone caused a marked increase in the hemolytic action. 

 Plasma obtained by immediately centrifugalizing the serum caused 

 little or no hemolysis in hemolytic cases. 



The hemolytic property reaches its maximum about 24 hours 

 after the blood is drawn. 



In the cancer group the cases in which the disease was entirely 

 removed lost their hemolytic property in from 12 to 21 days after 

 operation. 



In cases in which an incomplete operation was performed the 

 hemolysins continued indefinitely. 



Total number of cases studied 591. 









Per cent 



21 1 



No 







71 



7 







55 



No 







153 



130 





85 



1 1 



1 1 







Post operative cancer cases with 



clinical recurrence 



Post operative cases without clinical 



recurrence 3 weeks to 15 years 



after operation... 37 No hemolysis o 



Tuberculosis 52 48 hemolysis 92 



Our conclusion is that hemolysis occurs in a number of diseases. 

 It occurs in great frequency in cancer and tuberculosis. The re- 

 action in tuberculosis is the reverse of that of cancer. From the 

 clinical standpoint hemolysis offers additional evidence which may 

 be used in the diagnosis of cancer and tuberculosis. This evidence 

 is not as yet specific. 



