20 



Scientific Proceedings (30). 



the serum in several diseases has been undertaken. In this brief 

 report are given the results obtained in carcinoma and syphilis. 



The sera and corpuscles of 12 cases of carcinoma and 7 cases 

 of tertiary syphilis were examined. In 10 other cases of tertiary 

 syphilis, the corpuscles alone were examined. 



The experiments were planned in groups. In each group, the 

 corpuscles of at least one normal person, and several cases of 

 syphilis and carcinoma were exposed to the action of sera derived 

 from syphilitic and carcinomatous patients. 



The customary technic was employed, special care being taken 

 to use only fresh specimens of blood. Equal parts of serum and 

 of a one per cent, saline suspension of corpuscles (washed four 

 times) were incubated at 37° C. for one or two hours, sedimented 

 on ice over night, and compared with control tubes of the serum. 



In all 290 serum-corpuscle combinations were made. 



In this way were studied the actions of syphilitic and carcino- 

 matous sera on their own corpuscles, on normal corpuscles, and 

 on the corpuscles of other cases of syphiHs and carcinoma. 



The following results were obtained : 



Summary of Results. 



Out of the 12 cases of carcinoma, 4 showed the presence of 

 hemolysins in their sera, which caused laking of the erythrocytes 

 derived from normal human individuals. 



Out of the 7 cases of tertiary syphilis whose sera were ex- 

 amined, 6 showed the presence of hemolysins which dissolved the 

 corpuscles of normal persons. 



The corpuscles showed the following behavior : 



The corpuscles belonging to a hemolytic carcinomatous blood 

 were found to be immune to the action of the hemolysins in its 

 own serum or any other carcinomatous serum. 



The corpuscles belonging to a non-hemolytic carcinomatous 

 blood were readily laked by a hemolytic carcinomatous serum. 



Similarly the corpuscles of a hemolytic luetic blood were 

 found to be immune to the action of its own serum or any other 

 syphilitic serum. 



The corpuscles of a syphilitic blood, whose serum did not 

 contain hemolysins were laked by any hemolytic syphilitic serum. 



