Hemolysins in the Sera of Carcinoma and Syphilis. 21 



In every instance, it was found that the corpuscles belonging 

 to a hemolytic carcinomatous blood were immune to the action 

 of the hemolysins found in syphilitic serum. Conversely, the 

 corpuscles present in a hemolytic syphilitic blood were immune 

 to the action of the hemolysin present in carcinomatous serum. 



However, the corpuscles of a non-hemolytic carcinomatous 

 blood were readily laked by hemolytic syphilitic serum and simi- 

 larily the corpuscles of a non-hemolytic syphilitic blood were laked 

 by a hemolytic carcinomatous serum. 



Judging from the behavior of the sera towards the corpuscles 

 derived from various normal and diseased persons, one could not 

 distinguish a hemolytic syphilitic serum from a hemolytic carcino- 

 matous serum. 



This would suggest that the hemolysin found in syphilitic serum 

 is identical with one found in carcinomatous serum. 



It would seem, from the above results, that there is some con- 

 nection between the presence of a hemolysin in the blood and the 

 immunity of the corpuscles contained in that blood. 



The corpuscles found in hemolytic bloods — whether from 

 cases of carcinoma or syphilis — are immune to the action of the 

 hemolysins in those sera. The corpuscles of non-hemolytic bloods 

 are vulnerable and are readily laked by the hemolysins contained 

 in either carcinomatous or syphilitic sera. 



The reverse proposition could be argued from the results of 

 the above experiments. That is, if the corpuscles of a given blood 

 are immune to the action of a hemolytic serum, then the blood in 

 question contains a hemolysin. If the corpuscles are laked by a 

 hemolytic serum, then the blood in question does not contain hem- 

 olysin. 



The corpuscles of 10 other cases of tertiary lues (whose serum 

 was not obtained) were tested against the hemolysins in carcino- 

 matous and syphilitic sera. 



The corpuscles of 3 of these cases were easily laked by hem- 

 olytic sera derived from carcinomatous or syphilitic persons. 



The corpuscles of the other 7 cases were found to be immune 

 to the action of the hemolysins. 



It is reasonable to suppose that the 3 bloods with the vulner- 

 able corpuscles did not contain hemolysins, while the 7 bloods 

 containing immune or resisting corpuscles did contain hemolysins. 



