Hemolysins in the Sera of Carcinoma and Syphilis. 23 



eased focus could be assumed as the exciting cause of such an iso- 

 lysin formation. 



In conclusion, the writer wishes to acknowledge his indebted- 

 ness to Dr. J. E. Tuckerman, who collaborated in the research. 



12(350) 



The effect of instilling adrenalin chloride into the mammalian 



eye. 



By W. H. SCHULTZ. (By invitation.) 



\Froin the Division of Pharmacology, Hygienic Laboratory, 

 Washington, D. C] 



Certain writers have concluded that mydriasis cannot be pro- 

 duced by instilling adrenalin into the eye of higher animals except 

 under pathological conditions such as lesions of the pancreas or 

 the removal of the superior cervical ganglion. Perhaps this con- 

 clusion results from an oversight of the antagonism existing be- 

 tween the influence of instilled adrenalin and light stimuli when 

 simultaneously acting upon the intact eye. At any rate the con- 

 clusion is not supported by more recent experiments and is mis- 

 leading when used as a basis for diagnosing certain pathological 

 conditions. 



I have found that mydriasis can be produced in these animals 

 with relative ease and certainty. In making a comparative study, 

 however, of different degrees of susceptibility to adrenalin, due 

 care must be taken to keep the intensity of light stimuli constant. 

 This is essential, since in the eyes of higher mammals where the 

 light reflex is well developed, strong light may cause the pupil to 

 constrict to such an extent that any antagonism of this process by 

 adrenalin may be lost sight of For instance, by instilling adren- 

 alin into the normal cat eye for some minutes and then examin- 

 ing the eye in light bright enough to constrict the untreated eye 

 to a small slit-like aperture, no difference in the drugged and un- 

 drugged eyes can be detected ; but the same eyes examined in a 

 dark corner may show a distinct difference in the pupils, the 

 drugged pupil dilating more than the normal one. Thus the early 

 dilating effect of adrenalin can be detected more easily by reduc- 

 ing the intensity of the light stimuli. In this preliminary com- 



