Effect of Instilling Adrenalin Chloride. 25 



2. Nonnal gray rabbit. Sept. 3. Two drops of P., D. &Co.'s adrenalin chloride in- 



stilled every 2 minutes. 

 3.40 P. M. Right pupil 6. 6 X 9 ram., left 6.6 x 9.0 mm. 

 4.02 " " " lI.oxI2mra. 

 4.12 " " " 12.0x12.5 mm. 



4.38 " " " 13.5 x14 mm. Last instillation : left 7 x 10.4 mm., pupil 

 scarcely reacted to light. 



3. Large adult female cat. Aug. 20. P., D. & Co. I : looo. Instilled every 2 



minutes. 



10.30 A. M. Right and left pupils alike ; transverse diameter about mm. 

 10.34 " first instillation. 



11.48 " slight dilation of right eye, mm., left mm. 

 12.45 P. M. maximum dilation II. 2 mm., left i^ mm., practically no reaction 

 to light after loi minutes. 



4. Young adult female dog. Aug. 21. P., D. & Co.'s I : 1000 sol. of adrenalin 



chloride ; two drops every two minutes. 

 10.00 A. M. Right and left pupils of same diameter — about 4.2 mm, 

 10.04 " fij^st instillation. 



10.40 " right pupil about 5 mm., left 4.2 mm. 



11. 00 " " " " 6.8 mm., " 4.2 " 



II. 16 " " " " 9 mm., " 4.2 " 



11.40 " " " " II mm., " 4.2 " Last instillation. 

 4.30 P. M. " " " 2 mm., " 5 " 



Maximum dilation was reached after about 96 minutes at which time the pupil 

 ceased to react to fairly bright light from a skylight. By 4.30 the right pupil had not 

 only ceased to dilate, but even in such a light as one might secure in a well-lighted 

 room at 4.30 P. M., the drugged eye constricted much more than did the normal one. 



5. Monkey. P. , D. & Co.'s adrenalin chloride, i : looo. Two drops every two minutes. 



10.30 A. M. Both pupils of the same diameter, about 2.4 mm. 

 10.32 " first instillation. 



10.46 " 



right pupil 



2.6 mm.. 



left 2.4 



mm. 



10.49 " 



(( (t 



3.0 mm.. 



" 2.4 



c< 



II. 10 " 



<( {< 



3-5 mm., 



" 2.4 



t( 



II. 12 " 





4.0 mm.. 



" 2.4 



( i 



11.35 " 



ti 1 1 



5.4 mm., 



" 31 



1 1 



11.46 " 



tt tt 



6.0 mm. , 



" 30 



" pupils turned toward bright light. 



12.06 P. M. 



It (I 



6.5 mm.. 



" 2.8 



" constricted to about I mm. 



12.20 " 



It a 



7.0 mm.. 



" 2.8 



it 



12.40 " 



( ( ( ( 



8.4 mm., 



" 3-2 



" When turned toward bright light. 



the left pupil constricted to less than I mm. in diameter while the right constricted 

 but little (8.2 mm. ). 



1. 00 P. M. Last instillation, practically maximum dilation. 



5.00 " In dim light, right and left pupils about the same. 



Maximum dilation was reached after 148 minutes at the end of which time the 

 pupil no longer responded to bright light. Greater constriction of the right eye than 

 the left was noticed the following morning. 



In normal men, the resistance is still greater than in the monkey. 



