Effects of Extirpation of the Salivary Glands. 35 



When there are four different procedures for obtaining gastric 

 juice on the same dog within thirty minutes, and the jugular vein 

 exposed, a cannula inserted and submaxillary extract injected in- 

 travenously, it must not be overlooked that, with every additional 

 interference, the animal becomes more and more disturbed and that 

 this seriously influences his gastric secretion. The chemico-phys- 

 ical and the neuro-physical processes of secretion are thoroughly 

 upset unless a long time for recovery is given. This is shown in Dr. 

 Loevenhart's results, page 4 of his reprint, in which the total acid- 

 ity and free HCl and the proteolytic power became less and less 

 in specimens A, B and C; only when the psychic secretion was 

 aroused, granting that this was not a delayed effect of injection 

 sal. gl. extr. specimen D, was there any notable proteolysis with- 

 out addition of acid. The notes of the beginning of experimen- 

 tation on this dog bear the date of April 6, and the qualitative 

 studies bear the date of April 8 — not near time enough to permit 

 dog No. 2 to entirely recover. 



To expect salivary gland extract to raise the gastric secretion 

 qualitatively and quantitatively above what is the regular standard 

 for the average dog is to expect something abnormal — for an un- 

 usually abundant and unusually active gastric juice is logically 

 as abnormal as one that is unusually diminished or inactive. 



1. What Dr. Loevenhart presumes is that the salivary gland 

 extract should change a normal gastric juice to an abnormal one 

 (from the regular amount to an unusually high amount and activity). 



2. What I attempted to ascertain was whether or not an abnor- 

 mal gastric juice could be restored to the normal (from diminished 

 and weakened secretion to the normal). The " Fragestellung " is 

 not the same, in fact, it is highly digressing. 



Dr. Loevenhart observed only two animals. Nowhere does 

 he give the date of operations, nor state the time that elapsed 

 between the operation and first day of experimentation, nor the 

 amount of proteolysis in millimeters of Mett tubes. Both animals 

 were abnormal. The first dog, No. i, he admits had distemper 

 and was feverish, was thin and would not eat. The first observa- 

 tions are dated November 11, 1907, and this animal died within 

 48 hours. 



