Effects of Extirpation of the Salivary Glands. 37 



(the dog must be made to chew bread and then rapidly etherized). 

 I have worked with extracts of inactive glands, but so far have 

 refrained from publishing anything concerning their effects or non- 

 effect. In not a single instance, has the operative plan and tech- 

 nique used by us, nor the physiologic routine of preparing the 

 glands by functional work, nor the chemic discipline of ascertaining 

 the proteolytic activity been punctiliously carried out by Doctors 

 Loevenhart and Hooker. 



Both of the animals had diseased stomachs. In neither were 

 the salivary glands extirpated. The entire plan of experimentation 

 and aspect of physiologic inquiry is so fundamentally different from 

 mine, that comparison of their work with ours is not logical, and 

 any deductions from their work as used to interpret our results 

 are unfortunately misapplied. 



It is only fair that the work of an experimentor should be 

 judged from his most recent publication, in this case that which 

 appeared in the Biochemische Zeitschrift (Hamburger Festschrift, 

 Band xi, p. 238), the only complete report published by me. 



The short notice by which Drs. Loevenhart and Hooker judged 

 our work was nothing but a preliminary report, and contained, as 

 such reports occasionally do, some inaccuracies which I have 

 taken the privilege to correct in the article published in the Bio- 

 chem. Zeitschr., I. c. (" Die Wirkung der Total Extirpation Samt- 

 licher Speicheldriisen auf die Sekretorische Funktion des Magens 

 beim Hunde "). Even in this article the printer has allowed some 

 wrong figures to slip into the headings of tables C, D and F, pp. 

 257, 258 and 259, for which I am in no way responsible, but which 

 do not injure the main argument, especially as the editors of the 

 Biochem. Zeitschr. politely corrected them in a subsequent Be- 

 richtigung. 



In Dr. Loevenhart's experiment on April 8, submaxillary 

 extract was injected into dog No. 2 at about 3.10 to 3.15 P. M., 

 the gastric juice of twenty minutes later showed a free HCl of 

 0.20 (titration with «/20 NaOH) but the proteolytic power with 

 addition of acid is declared to be ''goody But at 3.30 the stomach 

 of the same dog was catheterized and specimen A obtained after 

 the dog was allowed to smell meat for ten minutes. This speci- 

 men A was the most active that Loevenhart obtained. It came 35 



