Life-saving Action of Eserin. 



47 



17 (355) 



Presentation of a dog ten months after double nephrectomy 

 and replantation of one kidney. 



By ALEXIS CARREL. 



[From the Rockefeller Institute for Medical Research.'] 

 The animal presented to the Society underwent the extirpation 

 and replantation of the left kidney and the extirpation of the right 

 kidney ten months ago. He is to-day in excellent health. 



The result shows that the perfusion of the kidney with Locke's 

 solution, the interruption of the renal circulation for fifty minutes 

 and the disconnection of the renal nerves with the central nervous 

 system do not produce any lesion of the kidney incompatible with 

 its functions. 



18 (356) 



A demonstration of the life-saving action of eserin in poi- 

 soning by magnesium. 



By DON R. JOSEPH and S. J. MELTZER. 



[From the Departmetit of Physiology and Pharmacology of the 



Rockefeller Institute for Medical Research^ 

 At the May meeting of this Society, one of us (J.) reported 

 that by the use of magnesium, certain toxic effects of physostig- 

 min can be completely overcome. In our present communication 

 we wish to bring out the fact that the antagonism between physo- 

 stigrain and magnesium is mutual, at least to a certain extent. We 

 wish to show an experiment which demonstrates that physostigmin 

 can overcome certain toxic effects of magnesium and thus save the 

 life of a poisoned animal. 



Both these rabbits (A and B) received at about the same time 

 1.2 gram of magnesium sulphate per kilo of body weight. The 

 injections were given intramuscularly in the lumbar region. Rabbit 

 B received in addition one milligram of eserin, also intramuscularly. 

 Rabbit A is already dead. Rabbit B is still alive ; although anes- 

 thetic and limp, it breathes regularly and apparently is in no 

 danger of death.' 



1 By the end of the meeting, rabbit B had recovered completely. 



