90 



Scientific Proceedings (32). 



42 (380) 



Further studies on the constitution of inosinic acid. 

 By WALTER A. JACOBS and P. A. LEVENE. 



[/v-f;« tlie Rockefeller Institute for Medical Research^ 



In a former paper ^ we have already communicated that the 

 inosin which we obtained from inosinic acid was identical with that 

 obtained from karnin by Haiser and Wenzel.^ We have now suc- 

 ceeded in isolating from inosin the pentose in a crystalline state. 

 The properties of this sugar are as follows : Melting point 87° C. 

 Its rotation in aqueous solution is {d^i^ = — 19°. 4. The osazone 

 melts at 163°- 164° C. and shows a rotation when 0.2 gram are 

 dissolved in 10 c.c. of a mixture of four parts pyridine to six parts 

 of alcohol of {d)j)= — 0° .g2. The benzylphenylhydrazone melts 

 at 1 28° C. and in absolute alcoholic solution rotates {d)j)= —26° .^6. 



We therefore conclude that this sugar is neither xylose nor 

 arabinose as stated by Neuberg and Brahm ^ and Bauer * respec- 

 tively. We hope, by further study, to establish its exact nature. 



43 (381) 



The effect of heat on the anaphylactic properties of proteins. 



B)' JOHN F. ANDERSON and M. J. ROSENAU. 



\_Fr07n the Hygienic Laboratojy, P. H. and M. H. S., 

 Washington, D. C] 



We have demonstrated that horse serum, egg-white and milk 

 when dried, then heated and redissolved, possess unaltered powers 

 of sensitizing and poisoning guinea-pigs in the sense of hypersus- 

 ceptibility. 



The above named substances, when thoroughly dried, were 

 heated to 130° C. for two hours, 150° C. for ten minutes, or 170° 

 C. for ten minutes. We have previously shown that both the sen- 

 sitizing and toxic properties of Hquid horse serum are gradually in- 



■ Prog. Soc. Exp. Med. and Biol., 1909, vi, 56. Ber. d. deutschen chem.Gesell., 

 X909, xlii, 335. 



^ Monatshefie fur Chemie, 1909, xxix, 157. 



^ Ber. d. deutschen chem. Gesell., 1908, xli, 3376. 



* Bcitra^e zur chem. Physiol, und Path., 1908, x, 345. 



