Observations on Effect of Asphyxia and Curare. 97 



general character, and especially the experience with uranium and 

 chromate sera of the dog, suggests that pressure-disturbing sub- 

 stances are present in the serum as the result of the kidney lesion. 

 The very slight evidence of the constant presence of a pressor 

 substance, however, offers little support to the theory that such a 

 substance is furnished by the diseased kidney or is due to dis- 

 turbances of metabolism caused by disease of the kidney. 



47 (385) 



Further observations on the effect of asphyxia and curare on 

 the reducing power of the blood after section of the 

 hepatic nerves in dogs. 



By J. J. R. MACLEOD. 



\_Froin the Laboratory of Physiology, Western Reserve University , 



Cleveland. '\ 



In a previous communication on this subject (Macleod, American 

 Jour, of Phys., 1909, XXIII, 278) it was concluded that section of 

 the hepatic nerves does not prevent the establishment of hypergly- 

 caemia as a result of asphyxia and curare poisoning (Table III, 

 p. 293, loc. cit.). The conclusion was based on the results of three 

 experiments in which asphyxia was practiced, and in two of which 

 marked hyperglycemia was observed ; and on one in which curare 

 was injected. Subsequent experiments of the same nature have 

 yielded results which do not corroborate the above conclusion for 

 asphyxiated animals, but do so for those which are curarized. 



The following table gives the results of these experiments : 



Per cent, of reducing substance in blood. 



No. and nature 

 of experiments. 



102 asphyxia 



104 asphyxia 



105 asphyxia 



107 asphyxia 



108 curare 



109 curare 

 no curare 



Before. 

 o. 104 



{I 



f 0.20 

 \ 0.21 



0.1 13 



/ o. 121 (30 min. 

 \o.\. 



244 

 244 

 200 



4 



0.265 



0.178 

 0.146 



After. 

 21 (30 

 147 (90 min 



0.262 (60 min. 



0.176 (45 mm. 



f 0.IS5 (45 min. 

 1 0.1 38 (75 min. 



0.304 (30 min. 



0 363 (45 min. 



0.354 (75 min. 



0.334 (40 min. 

 f 0.225 (60 min. 

 \ 0.272 (90 min. 



