CONVULSANT EFFECT OF REMOVAL OF HEART. 



31 



upon details: we shall merely state that the result was strikingly 

 positive. While the morphin frogs, which were kept with hearts 

 intact, remained normal, all the frogs which received proper doses 

 of morphin and had their hearts removed at different intervals, 

 developed tetanic convulsions, which in many cases had to be char- 

 acterized as very violent. With doses of 0.25 mg. per gram frog, con- 

 vulsions developed in practically every case, no matter how soon 

 or how late the heart was removed. After intervals of 60 minutes 

 and longer the result was positive practically with every dose 

 between 0.2 and 0.5 mg. per gram frog. (The essential points 

 were demonstrated before the Society.) 



12 (631) 

 Intravascular foreign bodies. 



By C. C. Guthrie and A. H. Ryan. 



[From the Laboratory of Physiology and Pharmacology, 

 University of Pittsburgh.] 



Experiments were performed by introducing sterilized (1) 

 untreated, (2) oiled silk, and (3) human hair into arteries and 

 veins and observing the results. Twelve common carotid arteries 

 and twelve external jugular veins were employed. The number 

 of silk strands varied from the smallest single strands used in 

 blood vessel suture to twenty-four such strands. Where a 

 number were used they were threaded into suitably large needles 

 and were not twisted. Cambric needles were used. 



The experiments were performed by exposing the vessels of 

 anesthetized dogs, transversely piercing the vessel with the 

 needle as near the mid-line as possible, drawing the ligatures 

 through and loosely tying the free ends together. Three weeks 

 later specimens were taken and examined. 



In no instance was there occlusion of the lumen nor was 

 there any evidence to indicate that the vessels would have sub- 

 sequently become occluded through thrombus formation. In 

 general the ligatures were found dividing the lumen and coated 

 with a substance closely resembling the intima in gross appear- 

 ance. 



