Character of colostrum in parturient paresis. 45 



of the first fresh colostrum of the cow obtained during an attack 

 of parturient paresis, upon the lower animals. We have not yet 

 been able to obtain a case of eclampsia. Accordingly eighteen 

 experiments have been carried out on guinea pigs. These experi- 

 ments have included a few other substances besides the first 

 colostrum of a cow suffering from parturient paresis, by way of 

 comparison, and these of course serve as controls on our other 

 results. Up to the present, therefore, the following substances 

 have been tested on the guinea pig, and in all instances were given 

 intraperitoneally, by hypodermic injection, using 10 c.c. or in 

 some cases less, viz., the first, fresh colostrum of the normal cow, 

 fresh milk from a high-class dairy herd, the first urine of a cow 

 suffering from parturient paresis, the urine of a healthy cow, 

 normal salt solution, and aqueous solutions of the residue from 

 colostrum and milk left after precipitating the same with dilute 

 acetic acid and finally the first, fresh colostrum of a cow, obtained 

 during an attack of parturient paresis. Briefly the following 

 results have been obtained. 



The normal salt solution, the urine of the healthy cow, and the 

 fresh milk from the healthy herd produce no bad effects when 

 injected intraperitoneally into guinea pigs. The first fresh colos- 

 trum of the normal cow produced diarrhea in the guinea pigs from 

 which they speedily recovered and these pigs are now alive and 

 well. The dried residue obtained by evaporating the filtrates from 

 normal colostrum after precipitating with dilute acetic acid and 

 neutralizing produced no effect. 



Three female guinea pigs received 10 c.c. each, of the first, 

 fresh colostrum of a cow in an attack of parturient paresis. (1) 

 The whole colostrum, (2) skimmed colostrum, (3) colostrum 

 cream. Pig I had no diarrhea, but died on the sixth day. On 

 post-mortem this pig showed acute parenchymatous nephritis 

 with interstitial hemorrhages, acute parenchymatous hepatitis 

 with interstitial hemorrhages, acute degeneration of the cells of 

 the adrenal cortex with complete destruction of the medullary 



728, the original of which appeared in the Annates de Med. Vet. de Bruxelles, July, 

 Aug., Sept., 1910, in which according to Hoyois the colostrum in cases of parturient 

 paresis, on intraperitoneal injection in doses of 10 to 20 grams, caused paralyzing 

 symptoms in rabbits and guinea pigs, with subsequent death at the end of seven to 

 twelve days. 



