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Scientific Proceedings (47). 



cells, and interstitial hemorrhages. No evidence of tuberculosis. 

 Cultures from the liver, kidney and spleen showed no micro- 

 organisms. No peritonitis. The pig was not pregnant. 



Pig 2 seemed well after the injection; had no diarrhea. Died 

 at the end of five days. On post-mortem showed acute paren- 

 chymatous nephritis, with interstitial hemorrhage, acute paren- 

 chymatous hepatitis, with interstitial hemorrhage, and marked 

 peripheral necrosis. Acute degeneration of the cells of the adrenal 

 cortex, with complete destruction of the medullary cells and inter- 

 stitial hemorrhages. No evidence of tuberculosis. The pig 

 was in the very early stages of pregnancy. Cultures from the 

 liver, spleen and kidneys negative. No peritonitis. 



Pig 3 seemed well after injection and had no diarrhea. Aborted 

 during first twelve hours after injection, fetus five and five tenths 

 cm. in length. Died in six days. The post-mortem showed acute 

 parenchymatous nephritis, with interstitial hemorrahges; acute 

 parenchymatous hepatitis, with areas of complete necrosis and 

 interstitial hemorrhages. Some degeneration of the cells of the 

 adrenal cortex with complete destruction of the medullary portion, 

 and interstitial hemorrhages. Acute lobar pneumonia of the left 

 lung. No tuberculosis. Pig no longer pregnant. Cultures from 

 the liver, kidney and spleen negative. Cultures from the pneu- 

 monic lung contained a diplococcus. No peritonitis except over 

 upper and anterior surfaces of the liver. 



A healthy male guinea pig received 10 c.c. of the first, fresh, 

 clear urine of a cow ill with parturient paresis. This pig showed 

 no discomfort and no diarrhea. It developed a very marked 

 diuresis however, passing at least 200 c.c. of urine in 24 hours. 

 This urine contained a small amount of albumin and no sugar. 

 This pig recovered from the diuresis and seemed well, and was 

 chloroformed on the 13th day. On post-mortem this pig showed 

 parenchymatous nephritis with some interstitial hemorrhage, a 

 rather extensive necrosis of the liver cells, but without hemorrhage, 

 and also localized areas of necrosis in the adrenals. 



It is evident from these results that normal salt solution, fresh 

 milk, and the urine of a healthy cow cause no disturbances in 

 healthy guinea pigs. The colostrum of the normal cow invariably 

 produced a diarrhea when injected into the peritoneal cavity of 



