Some Vaso-Reacting Substances in Blood Serum. 51 

 Contaminated sera cause depressions. 



An antimeningococcus serum, which had produced rashes in 

 humans caused well-marked depressions in c.c. doses. 



Serum of a diphtheria antitoxin horse, which was recovering 

 from an attack of indigestion gave a slight depression. This serum 

 was secured through the courtesy of Dr. Banzhaf . 



These observations have extended over a period of 2^ years. 



Note. — We have already reported depressions from the injec- 

 tion of the sera of tuberculous rabbits and from the injection of 

 tuberculins as well as from the injection of the sera of animals in- 

 oculated subdurally with normal and hydrophobic brain tissue 

 emulsion. 



36 (645) 



A study by the Meyer method of the effect of blood serum and 

 certain inorganic salts on surviving arteries. 



By E. A. PARK and J. C. JANEWAY. 



[Department of Medicine, Columbia University.] 

 The method employed is an adaptation of the Meyer ox 

 carotid method. Instead of strips from the carotid, rings from 

 the mesenteric or hepatic arteries of the ox strung in pairs were 

 used, and from the coronary arteries as controls. Adrenalin, 

 even in every dilute solution, constricts the former, while it 

 causes the coronary to dilate, whether it be added to Ringer- 

 Locke fluid, or to the ox blood serum. This method, then, 

 based on the contrary effects produced by adrenalin on two 

 kinds of arteries, each possessing a different reactive property 

 to adrenalin, should be ideal for the detection of adrenalin and 

 the separation of it from the confusion with other substances in 

 the blood serum exerting a constrictor or dilator action. Ox 

 blood serum as opposed to adrenalin produces a constriction of 

 both coronary and mesenteric or hepatic arteries. Thus it 

 essentially differs in its action from adrenalin. There is, then, 

 so far as surviving arteries are concerned, a vasoconstrictor 

 property of ox blood serum, not to be explained by the presence 

 of adrenalin. 



The constriction produced by ox blood serum on ox arteries 



