52 



Scientific Proceedings (47). 



occurs abruptly after a latent period of only a few seconds and 

 is comparable in its intensity to that produced by adrenalin on 

 the mesenteric or hepatic arteries. The duration is at least four 

 hours, the limit of our means for recording it. Passing oxygen 

 through it weakens this constricting property, as does time, 

 i. e., allowing it to stand one or two days at room temperature. 

 Adrenalin added to blood serum even at the height of a contrac- 

 tion further increases it in the case of hepatic and mesenteric 

 arteries, but produces an especially marked relaxation in the 

 case of the coronary artery. Adrenalin added to fresh ox blood 

 to make a proportion of one to 800,000, we have identified thirty- 

 six hours later ; and when added to make a proportion of one to 

 100,000 after seven hours' oxygenation under a pressure of more 

 than 100 millimeters mercury at incubator temperature. 



Sodium chloride in dilution less than .01 produces a marked 

 constriction of the above-named arteries as compared with 

 Ringer-Locke fluid. The latent period is longer than that of 

 adrenalin or ox blood serum, the ascent more gradual; moreover 

 the height of the curve seems to vary inversely to the sodium 

 chloride water ratio to a point .005, below which we have not 

 investigated. At .013 sodium chloride the strips of artery appar- 

 ently die. The relations of calcium and potassium to tonus have 

 not been taken up yet. Barium chloride produces a vasocon- 

 striction which exceeds that produced by adrenalin, or, so far 

 as our experience goes, any other substance. The curve produced 

 by it tends to be irregular, frequently assuming a staircase 

 character. 



37 (646) 



The influence of the sugar concentration of the blood on the 

 protein metabolism in phlorhizin diabetes. 



By A. I. RINGER. 



[From the Department of Physiological Chemistry 

 of the University of Pennsylvania.] 

 According to Rubner, the protein metabolism of a normal 

 starving animal is composed of two fractions : 

 I. Wear and tear quota. 



