Protein Metabolism in Phlorhizin Diabetes. 53 



II. Dynamogenetic quota. 



The first fraction represents the protein metabolized in the life 

 processes of the cells. The second fraction represents the protein 

 burnt for the purpose of maintaining the temperature of the body. 



Landergren, however, presents considerable evidence to show 

 that the "dynamogenetic quota" of Rubner is really the result 

 of two distinct processes: 



I. The protein that is metabolized for the increased pro- 

 duction of sugar, in cases where sugar is absent from the diet and 

 the glycogen supply becomes low. 



II. For the maintenance of body temperature. 



It is a well-known fact, that in phlorhizin diabetes, the pro- 

 tein catabolism rises enormously; in some cases as high as five 

 times the starvation requirements. Because of the renal origin 

 of the glycosuria, there is a constant tendency for the concen- 

 tration of the sugar in the blood to fall. The following experi- 

 ment was performed in order to test what part, if any, the con- 

 centration of the sugar in the blood plays in the regulation of the 

 protein metabolism. 



A dog was phlorhizinized in the usual manner, and the D : N 

 ratio established. Seventy-five grams of glucose dissolved in 

 water and divided into six doses were given per os on the fourth 

 day of the glycosuria. 150 grams were given on the sixth day. 



The results are here tabulated : 



Dog No. 11. 



Date. 



Period. 



Weight. 



Total 

 N. 



Total Sugar. 



D:N. 



Remarks. 



February, 















1912 















IS" 



III. 



17-53 



1440 



52.08 



3-62 





16 



IV. 



17.24 



9-32 



IO3.IO 



11.06 



75 gm. of glucose given per os. 



17 



V. 



16.86 



14.00 



50-95 



3-64 





18 



VI. 



16.60 



7.18 



127.17 



17.71 



150 gm. of glucose given per os. 



19 



VII. 



16.25 



7.78 



56.29 



7-23 





20 



Animal died under anesthesia, while a sample of blood was being with- 



drawn from the carotid artery. 



From the D : N ratio on the third and fifth days, we may assume 

 that the phlorhizin intoxication was complete and that the protein 

 burnt on the fourth, sixth and seventh days yielded 3.6 gm. of 

 glucose for every gram of nitrogen. 



