54 



Scientific Proceedings (47). 



The amount of glucose eliminated on the fourth day was 103. 1 

 gm. By subtracting 33.55 gm., which originated from the 

 protein (9.32 X 3-6), we find that 69.5 gm. of the 75 gm. of 

 glucose fed, were eliminated unburnt. By applying similar 

 calculations to the results obtained on the sixth and seventh days, 

 we find that the protein metabolized during the sixth day yielded 

 (7.18 X 3-6) 23.85 gm. of glucose, and during the seventh day 

 (7.78 X 3-6) 28.01 gm. The total amount of glucose eliminated 

 during these two days was 183.46 gm. By subtracting the glucose 

 that was derived from the protein, we find that 131. 6 gm. of the 

 150 gm. of glucose ingested were eliminated unburnt. 



The nitrogen metabolism was diminished by a little more than 

 5 gm. on the fourth day and was reduced almost fifty per cent, 

 on the sixth and seventh days. If the increase in the protein 

 metabolism in phlorhizin diabetes were due to dynamogenetic 

 reasons only, the burning of 5.5 gm. of glucose on the fourth 

 day could not have spared the combustion of 31.8 gm. of protein. 

 Nor could the burning of 18.4 gm. of glucose on the sixth and 

 seventh days have spared as much as 81 gm. of protein. 



From this experiment it is apparent that in phlorhizin diabetes, 

 extra protein is catabolized in order to maintain the glucose 

 concentration of the blood which, perhaps for some physico- 

 chemical reason, is essential to the processes of life. The intro- 

 duction of glucose into the system, although very little of it is 

 burnt, spares that amount of protein. 



It is also noteworthy in this experiment that the 150 gm. of 

 glucose given within 12 hours were not eliminated completely 

 during the first 24 hours, but were carried over to a great extent 

 to the second 24 hours. 



38 (647) 



The influence of glutaric acid on phlorhizin diabetes. 



By A. I. RINGER. 



[From the Department of Physiological Chemistry of the University 

 of Pennsylvania, Philadelphia, Pa.] 

 Baer and Blum found that the subcutaneous injection of 10 

 gm. of glutaric acid had the power of greatly reducing the amount 



