6 4 



Scientific Proceedings (47). 



45 (654) 



Preliminary note on the pineal gland and the corpus luteum. 

 By ISAAC OTT, M.D., and JOHN C. SCOTT, M.D. 



In a series of experiments we have found the pineal gland to 

 have a marked diuretic action, previously noted by Eyster. At 

 the time of each injection per jugular the volume of the kidney 

 increases considerably, whilst, after a temporary fall, the pressure 

 in the carotid shows some increase. About one half of one per 

 cent, of glucose appears in the urine after the injection of pineal 

 extract and after the use of corpus luteum. 



Corpus luteum does not markedly change the pulse rate, but 

 lowers blood-pressure 20-40 millimeters of mercury, and then it 

 rises above normal for a short time. The intestinal peristalsis is 

 markedly increased by corpus luteum. 



In the pregnant uterus, corpus luteum increased the contrac- 

 tions. 



46 (655) 



The spleen and chronic constipation. 



By ISAAC OTT, M.D., and JOHN 0. SCOTT, M.D. 



In the Medical Bulletin, 1897, one of us (Ott) stated, the spleen 

 of all the animal extracts has the most marked effect on peristalsis. 

 It produces the largest peristaltic waves. When the spleen was 

 removed then peristalsis decreased. If now spleen extract was 

 injected, then peristalsis was restored to a considerable extent 

 above normal. 



In 1908, Zuelzer (Dohrn, Marxer and Zuelzer, "Specifische 

 Aufregung der darm Peristaltik, etc.," Berliner Klinische Wochen- 

 schrift, 1908, No. 48) with others confirmed the preceding results. 

 He prepared an extract of the spleen, called " hormonal," for intra- 

 venous and intramuscular injection in man for the cure of chronic 

 constipation. He reports marked success in this condition. This 

 statement has been confirmed by Saar, Henle, Unger and several 

 others. 



