70 



Scientific Proceedings (47). 



by electrical change. Marked hyperirritability was present in 

 one case for 1 1 months without other symptoms of tetany. 



7. Sixteen dogs at some time during their periods of observa- 

 tion gave response to all forms of current at less than 5 m.a. 

 Seven dogs with all parathyroids absent were constantly low in 

 all reactions. Five dogs, 2 with all glands removed, 3 with 2 

 removed, I with 3 removed, were constantly low in all but K.O. 

 Four dogs, 3 with 2 glands removed, 1 with 3 removed, gave con- 

 stantly varying reactions. 



In one instance there was constant low K.C., high K.O. and 

 great variation in the anodal tests. 



As a rule the electrical change is sufficiently constant to make 

 the test a valuable one. Variations are, however, to be expected. 



8. Eight dogs, 2 with I gland, 4 with 2 glands, 2 with 3 glands 

 removed showed marked and complete electrical hyperirritability 

 without other symptoms of tetany. Parathyroid injury sufficient 

 to produce hyperirritability does not necessarily result in frank 

 tetany. 



9. Eight dogs were subjected to parathyroid injury and later 

 to further loss of glands. In each instance the electrical changes 

 following second operation were more rapid in development and 

 more severe than those noted after the first operation. 



10. While under observation 2 parathyropriva dogs littered 

 normally and 1 aborted at about 1 month. None developed 

 tetany during gestation or lactation. There was moderate in- 

 creased irritability during gestation which became more marked 

 during lactation. No electrical change occurred in the animal 

 which aborted. 



