Inhibitory Action of Adrenalin. 



79 



experiments. In 6 of the 10 positive experiments, there was an 

 actual increase in the amount of reducing substance during the 

 course of the experiment. 



The results may be summarized as follows: 



These experiments then show that the antagonistic action between 

 adrenalin and pancreas, as schematized by Falta, Eppinger and 

 Rudinger, may be demonstrated in vitro independently of any 

 possible nervous influence. King in 1910 showed that a similar 

 retarding influence upon the disappearance of reducing substance 

 in muscle pancreas mixtures was exerted by thyroid extract. 



The question as to whether there occurs in this reaction, a 

 true glycolysis, or as Levene and Meyer hold, merely a condensa- 

 tion of the sugar molecule, is left untouched by these experiments. 

 The antagonistic action of adrenalin and pancreas in regard to the 

 disappearance of reducing substance in muscle extracts seems to 

 be clearly demonstrated. 



The characteristic course of the rise of blood pressure caused 

 by an intraspinal injection of adrenalin. 



By J. ATJER and S. J. MELTZER, 



[From the Department of Physiology and Pharmacology of the 

 Rockefeller Institute.] 



An intravenous injection of adrenalin causes a rapid steep rise 

 of the blood pressure with a gradual fall. An intramuscular in- 

 jection produces a similar effect. A subcutaneous injection either 

 produces practically no effect or it causes a very slow rise which 

 rarely exceeds fifteen millimeters. In recent years adrenalin was 

 injected into the spinal canal in conjunction with some local 

 anesthetic. The question as to the nature of the effect of these 

 injections upon the blood pressure has to our knowledge never yet 

 been investigated. On the basis of the generally accepted assump- 

 tion that the absorption from the spinal canal into the circulation 



Muscle-extract alone 



Muscle- pancreas 



M uscle- pancreas-adrenalin 



Mixture. 



Average Loss of Re- 

 ducing Substance. 



— 0.096 gm. in 100 c.c. 



— 0.225 gm. in 100 c.c. 

 + 0.01 gm. in 100 c.c. 



58 (667) 



