Vomiting Movements in an Eviscerated Animal. 8i 



59 (668) 



Demonstration of vomiting movements in an eviscerated 

 animal under the influence of digitalis. 



By 0. EGGLESTON and R. A. HATCHER. 



[Laboratory of Pharmacology of Cornell University Medical College.] 



It is commonly accepted that apomorphine produces emesis 

 through its action on the center in the medulla concerned in 

 emesis, but that digitalis produces emesis through its irritant 

 action on the stomach. 



We had some evidence that digitalis produced vomiting 

 through its central action and decided to carry out as many experi- 

 ments as possible of those which had been made in establishing 

 the seat of action of apomorphine, but substituting digitalis, and in 

 the course of the investigation we utilized a method which has 

 not been described hitherto, and which consists in the removal 

 of the gastro-intestinal tract from the esophagus to the anus, 

 after tying the vessels which supply the tract, and injecting 

 digitalis intravenously after an appropriate interval of time, 

 varying from a few minutes to an hour and a half. 



We have produced vomiting movements in about fifty per 

 cent, of the experiments so made, and nausea in all but one of the 

 others, and barring those experiments where the depression from 

 the operation seemed to indicate that nausea could not be induced, 

 the percentage of successful experiments is still higher. 



Using apomorphine intramuscularly, we have been able to 

 produce vomiting movements in nine out of ten such experiments 

 on the dog. 



60 (669) 



The variations of pressure in the pulmonary artery. 



By CARL J. WlGGERS. 



[From the Physiological Laboratory, Cornell University Medical 

 College, New York City.] 



The systolic and diastolic pressures existing in the pulmonary 

 artery of naturally breathing dogs have not been heretofore 

 investigated. By means of a sensitive pulse pressure instrument 



