2 



Scientific Proceedings (50). 



In order to answer this question, the nasal mucous membrane 

 of a Macacus rhesus monkey was swabbed lightly with a portion 

 of ground cord from a recently paralyzed monkey. The monkey 

 was killed at the end of 48 hours and the following portions of the 

 central nervous system were removed separately and aseptically: 

 (1) the olfactory lobes with small portions of the adjacent brain 

 substance, (2) the medulla, and (3) pieces of the cord at different 

 levels including the cervical and lumbar enlargements. These 

 different portions were injected separately as suspensions into 

 the brain and peritoneal cavity of three other Macacus rhesus 

 monkeys. 



The monkey injected with the suspension of the olfactory lobes 

 came down in a manner typical of poliomyelitis in monkeys with 

 definite prodromal symptoms on the ninth day, paralysis on the 

 tenth and death on the twelfth day. At autopsy, lesions char- 

 acteristic of the disease were observed throughout the cord. 



The two other monkeys remained entirely well and have never 

 shown any symptoms of paralysis. 



The result of this experiment is definite. The virus of polio- 

 myelitis passes from the nasal mucous membrane to the olfactory 

 lobes and adjacent parts of the brain before it reaches the medulla 

 or cord. This distribution is what we would expect were the 

 ascent by the direct lymphatic path and not by the blood stream. 

 Were the dissemination by the latter route we should expect 

 early localization in those parts of the cord and medulla that 

 possess an especial affinity for the virus. 



2 (698) 



Effects on meningeal tuberculosis of the local injection of foreign 



leucocytes. 



By Wilfred H. Manwaring. 



[From the Rockefeller Institute for Medical Research.} 



In a previous report, 1 it was shown that the use of foreign 

 leucocytes as a local therapeutic agent in experimental meningeal 

 infections in dogs is limited by the toxicity of foreign leucocytes 



1 Vol. IX, p. 117. 



