24 



Scientific Proceedings (51). 



the anterior lymph hearts, in addition to cardiectomy the alkaloids 

 under discussion did not bring on any convulsions. I shall not 

 enter here into a discussion of the entire subject. I merely wish 

 to let you witness some indisputable facts. You see here a series 

 of frogs from whom the thoraco-abdominal viscera have been 

 removed, and in addition, the lymph hearts were destroyed by 

 cauterization. All these animals were injected about an hour 

 ago with strychnin; the injections were made in some animals 

 into the dorsal lymph sac and in others into the femoral sacs of 

 both thighs. You see that they respond to a tap with a tetanus. 

 This shows definitely that the injected strychnin reached the 

 central nervous system of these completely eviscerated frogs 

 without the help of the anterior lymph hearts. But you see also 

 that the trays holding the frogs are kept over ice. This is done 

 because at the room temperature, I could not be sure of the 

 success of my demonstration. It is possible that Abel's observa- 

 tions were made in May, when such experiments are apt to fail. 



17 (713) 



Pulmonary lesions by intra-bronchial insufflation of cultures of 

 B. megatherium. With a demonstration. 



By Martha Wollstein and S. J. Meltzer. 



[From the Laboratories of the Rockefeller Institute for Medical 



Research.] 



The production of experimental pneumonia in dogs by means 

 of intra-bronchial insufflation of bacterial cultures has now been 

 carried out in several series of investigations. In the first series 

 Lamar and Meltzer produced lobar pneumonia by insufflation of 

 cultures of a virulent pneumococcus. In a second series we 

 produced lobular pneumonia by insufflation of a virulent strepto- 

 coccus and of the influenza bacillus. Besides the differences in the 

 gross appearances of the lesions both pneumonias offered the 

 following distinguishing points: In the lobar pneumonia of the 

 virulent pneumococcus there was a mortality of about 16 per 

 cent.; even in the non-fatal cases there was bacteremia present 

 in the first twenty-four hours; the exudate was rich in fibrin 

 and the framework of the lungs was invariably free from leucocytic 



